Evidence map›Paper›PMID 25885520›Full record

ArticleThe British journal of nutrition2015

Endothelial function, arterial stiffness and adherence to the 2010 Dietary Guidelines for Americans: a cross-sectional analysis.

Katherine A Sauder, David N Proctor, Mosuk Chow, Lisa M Troy, Na Wang, Joseph A Vita, Ramachandran S Vasan, Gary F Mitchell, Paul F Jacques, Naomi M Hamburg and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The British journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Obesity impacts the expression of Alzheimer's disease-related genes: The Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
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  16. Association Between Dietary Fiber Intake and Bone Loss in the Framingham Offspring Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Article
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Katherine A SauderDepartment of Biobehavioral Health,Pennsylvania State University,219 Biobehavioral Health Building,University Park,PA16802,USA.
David N ProctorDepartment of Kinesiology,Pennsylvania State University,University Park,PA,USA.
Mosuk ChowDepartment of Statistics,Pennsylvania State University,University Park,PA,USA.
Lisa M TroyDepartment of Nutrition, University of Massachusetts,Amherst,MA,USA.
Na WangData Coordinating Center, Boston University School of Public Health,Boston,MA,USA.
Joseph A VitaEvans Department of Medicine, Boston University School of Medicine,Boston,MA,USA.
Ramachandran S VasanEvans Department of Medicine, Boston University School of Medicine,Boston,MA,USA.
Gary F MitchellCardiovascular Engineering, Inc.,Norwood,MA,USA.
Paul F JacquesJean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University,Boston,MA,USA.
Naomi M HamburgEvans Department of Medicine, Boston University School of Medicine,Boston,MA,USA.
Sheila G WestDepartment of Biobehavioral Health,Pennsylvania State University,219 Biobehavioral Health Building,University Park,PA16802,USA.
Boston University · USPennsylvania State University · USTufts University · USUniversity of Massachusetts Amherst · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
NIDDK National Research Service Award (NRSA) T32 Diversity Administrative SupplementT32DK007658 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Kristen Elizabeth Boyle, Ihuoma U Eneli · 1991 to 2026
$6.0M
Framingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9M
Ventricular Vascular Coupling: Correlates and PrognosisR01HL080124 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$3.4M
Biomarkers of Ventricular and Vascular RemodelingR01HL077447 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$2.6M
Vascular Function in the Framingham Third GenerationR01HL070100 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2002 to 2005
$2.4M
ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTIONK24HL004334 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2001 to 2008
$707k
ENDOTHELIAL VASAMOTOR FUNCTION IN THE FRAMINGHAM STUDYR01HL060040 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 1999 to 2002
$595k
Genetics of Oxidative Stress in Ventricular RemodelingR01HL071039 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S. · 2002 to 2003
$252k
The Effect of Diet on Age-Related Arterial Stiffness and Endothelial DysfunctionF31AG043224 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI SAUDER, KATHERINE A. · 2012 to 2013
$73k
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1TR000127NHLBI NIH HHS 2-K24-HL04334NHLBI NIH HHS HL070100NHLBI NIH HHS HL071039NHLBI NIH HHS HL076784NHLBI NIH HHS HL077447NHLBI NIH HHS HL080124NHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01-HC-25915NHLBI NIH HHS R01 HL060040NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL071039NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL077447NHLBI NIH HHS R01 HL080124NIA NIH HHS F31 AG043224NIA NIH HHS F31AG043224NIDDK NIH HHS T32 DK007658NIDDK NIH HHS T32DK07658
6 · The paper itself

Abstract

Endothelial dysfunction and arterial stiffness are early predictors of CVD. Intervention studies have suggested that diet is related to vascular health, but most prior studies have tested individual foods or nutrients and relied on small samples of younger adults. The purpose of the present study was to examine the relationships between adherence to the 2010 Dietary Guidelines for Americans and vascular health in a large cross-sectional analysis. In 5887 adults in the Framingham Heart Study Offspring and Third Generation cohorts, diet quality was quantified with the 2010 Dietary Guidelines Adherence Index (DGAI-2010). Endothelial function was assessed via brachial artery ultrasound and arterial stiffness via arterial tonometry. In age-, sex- and cohort-adjusted analyses, a higher DGAI-2010 score (greater adherence) was modestly associated with a lower resting flow velocity, hyperaemic response, mean arterial pressure, carotid-femoral pulse wave velocity (PWV), and augmentation index, but not associated with resting arterial diameter or flow-mediated dilation (FMD). In multivariable models adjusting for cardiovascular risk factors, only the association of a higher DGAI-2010 score with a lower baseline flow velocity and augmentation index persisted (β = - 0·002, P= 0·003 and β = - 0·05 ± 0·02, P< 0·001, respectively). Age-stratified multivariate-adjusted analyses suggested that the relationship of higher DGAI-2010 scores with lower mean arterial pressure, PWV and augmentation index was more pronounced among adults younger than 50 years. Better adherence to the 2010 Dietary Guidelines for Americans, particularly in younger adults, is associated with a lower peripheral blood flow velocity and arterial wave reflection, but not FMD. The present results suggest a link between adherence to the Dietary Guidelines and favourable vascular health.

Indexed as

Nutrition PolicyPatient ComplianceAdultArterial PressureBlood Flow VelocityBrachial ArteryCardiovascular DiseasesCross-Sectional StudiesEndothelium, VascularFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisNutrition AssessmentArterial stiffnessDietary Guidelines for AmericansEndothelial functionFramingham Heart Study

Identifiers

PMID25885520
PMCPMC4466070
OpenAlexW2011167794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.