ArticleParasites & vectors2015
Differential effect of human ivermectin treatment on blood feeding Anopheles gambiae and Culex quinquefasciatus.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Ivermectin treatment in humans for reducing malaria transmission.The Cochrane database of systematic reviews · 2021Pooled it
- Malaria vector research and control in Haiti: a systematic review.Malaria journal · 2016Pooled it
- Trial
- Efficacy of high doses of ivermectin-clorsulon in cattle on Glossina palpalis gambiensis survival and fecundity: implications for human and animal trypanosomoses control.Parasites & vectors · 2026Article
- Article
- Comparative susceptibility of wild and laboratory-reared Aedes and Anopheles larvae to ivermectin.Malaria journal · 2025Article
- Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s.Parasites & vectors · 2023Article
- Effect of IvermectinMalaria journal · 2023Article
- Ivermectin as an endectocide may boost control of malaria vectors in India and contribute to elimination.Parasites & vectors · 2022Review
- Lymphatic filariasis, infection status in Culex quinquefasciatus and Anopheles species after six rounds of mass drug administration in Masasi District, Tanzania.Infectious diseases of poverty · 2021Article
- The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes.PLoS pathogens · 2021Article
- High concentrations of membrane-fed ivermectin are required for substantial lethal and sublethal impacts on Aedes aegypti.Parasites & vectors · 2021Article
- Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania.Journal of clinical medicine · 2020Article
- The effect of ivermectinMalaria journal · 2019Article
- Effect of LongRange™ eprinomectin on Anopheles arabiensis by feeding on calves treated with the drug.Malaria journal · 2019Article
- Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Repellent Activity of TRIG (N-N Diethyl Benzamide) against Man-Biting Mosquitoes.Journal of tropical medicine · 2018Article
- Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles.Malaria journal · 2017Article
- Effect of physicochemical parameters on Anopheles and Culex mosquito larvae abundance in different breeding sites in a rural setting of Muheza, Tanzania.Parasites & vectors · 2017Article
- Ivermectin-treated cattle reduces blood digestion, egg production and survival of a free-living population of Anopheles arabiensis under semi-field condition in south-eastern Tanzania.Malaria journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWidespread and large scale use of ivermectin in humans and domestic animals can have unexpected effects on non-target organisms. As a search for a possible explanation for an observed longitudinal decline in density of anopheline vector mosquitoes, but not in Culex quinquefasciatus, in an area of north-eastern Tanzania which has been exposed to ivermectin mass drug administration, this study assessed and compared the effect of human ivermectin treatment on blood feeding Anopheles gambiae and Cx. quinquefasciatus.
methodsConsenting adult volunteers were randomized into two groups to receive either ivermectin or placebo. Twenty four hours after treatment, one volunteer from each group was concurrently exposed to 50 laboratory reared An. gambiae on one arm and 50 laboratory reared Cx. quinquefasciatus on the other arm for 15-30 minutes. Engorged mosquitoes were maintained on 10% glucose solution for 12 days and observed for survival and fecundity. The experiment was repeated 15 times.
resultsTwo days after the blood meals, nearly half (average 47.7% for the 15 experiments) of the blood fed An. gambiae in the ivermectin group had died while almost all in the placebo group were alive (97.2%), and the difference in survival between these two groups continued to widen on the following days. There was no clear effect of ivermectin on Cx. quinquefasciatus, which had high survival in both ivermectin and placebo group on day 2 (95.7% and 98.4%, respectively) as well as on the following days. Ivermectin completely inhibited egg laying in An. gambiae, while egg laying and subsequent development of immature stages appeared normal in the other three groups.
conclusionBlood meals taken on ivermectin treated volunteers significantly reduced survival and halted fecundity of An. gambiae but had only limited or no effect on Cx. quinquefasciatus. The result suggests that widespread use of ivermectin may have contributed to the observed decline in density of An. gambiae, without similar decrease in Cx. quinquefasciatus, in north-eastern Tanzania.
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Registered trials
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