ArticleBMC cancer2015
The prognostic significance of age in operated and non-operated colorectal cancer.
Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Lymph node yield does not affect the cancer-specific survival of patients with T1 colorectal cancer: a population-based retrospective study of the U.S. database and a Chinese registry.International journal of colorectal disease · 2025Article
- Prognostic Nomograms to Predict Survival of Patients with Resectable Gallbladder Cancer: A Surveillance, Epidemiology, and End Results (SEER)-Based Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Long-term outcomes of colorectal cancer surgery for elderly patients: a propensity score-matched analysis.Surgery today · 2020Article
- Long-term outcomes and prognostic factors of young patients with mucinous and signet-ring cell colorectal cancer.Archives of medical science : AMS · 2020Article
- Oncologic Outcome and Efficacy of Chemotherapy in Colorectal Cancer Patients Aged 80 Years or Older.Frontiers in medicine · 2020Article
- Using nomograms to predict prognostic factors in young colorectal mucinous and signet-ring cell adenocarcinoma patients.Bioscience reports · 2019Article
- Prognosis Prediction of Colorectal Cancer Using Gene Expression Profiles.Frontiers in oncology · 2019Article
- Oncologic outcome of colorectal cancer patients over age 80: a propensity score-matched analysis.International journal of colorectal disease · 2018Article
- Nomograms incorporated serum direct bilirubin level for predicting prognosis in stages II and III colorectal cancer after radical resection.Oncotarget · 2017Article
- Adjuvant radiotherapy improves cause specific survival in stage II, not stage III mucinous carcinoma of the rectum.BMC cancer · 2017Article
- High expression of Zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage II/III colorectal cancer patients.Oncotarget · 2016Article
- Effect of Age on Survival Outcome in Operated and Non-Operated Patients with Colon Cancer: A Population-Based Study.PloS one · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic significance of age in colorectal cancer remains controversial. Our purpose was to determine the impact of age at diagnosis on cause- specific survival and overall survival in patients with colorectal cancer.
methodsUsing Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 226,430 patients with colorectal cancer diagnosed between 1996 and 2005. Patients were separated into 10-year age groups. Five-year cancer cause-specific survival and overall survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors.
resultsIn the operated group, those aged 51-60 had the best prognosis with 5-year cause-specific survival of 72.3% and 5-year overall survival of 68.3%.In the non-operated group, those of young age 15-30 had the best prognosis with 5-year cause-specific survival of 21.2% and 5-year overall survival of 18.2%, and there was continued worsening in cause-specific survival and overall survival with increasing age, except for a small increase in the 51-60 age group (P < 0.001). Multivariable analysis demonstrated a statistically significant disadvantage in cause-specific survival in patients older than 60 (P < 0.001), but the difference between the 51-60 age group and the younger age group (15-30, 31-40, 41-50) wasn't statistically significant (P > 0.05) in both operated and non-operated patients.
conclusionsThere was no apparent difference in survival in colorectal cancer patients 60 and younger, but in those older than 60 years, there was worsening in overall survival and cause-specific survival in both operated and non-operated patients.
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