Evidence map›Paper›PMID 25885254›Full record

ArticleJournal of translational medicine2015

Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model.

Qiwen Deng, Bangshun He, Xian Liu, Jin Yue, Houqun Ying, Yuqin Pan, Huiling Sun, Jie Chen, Feng Wang, Tianyi Gao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 10 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 10 syntheses or guidelines pooled it, 213 citations in OpenAlex.

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  7. The diagnostic efficacy of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in ovarian cancer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017
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  11. The prognostic value of derived neutrophil to lymphocyte ratio in oesophageal cancer treated with definitive chemoradiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2017
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  14. Correlations ofQuantitative imaging in medicine and surgery · 2026
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84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Qiwen DengCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. qiw_deng@163.com.
Bangshun HeCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. 1061851556@qq.com.
Xian LiuCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. 2697250365@qq.com.
Jin YueDepartment of Laboratory Medicine, Huai'an Second People's Hospital, Huai'an, Jiangsu, China. jinjun_hou@163.com.
Houqun YingCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. 570154244@qq.com.
Yuqin PanCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. 2339820358@qq.com.
Huiling SunCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. sunhuiling1988@yeah.net.
Jie ChenCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. tiany_gao@163.com.
Feng WangCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. 18262638632@139.com.
Tianyi GaoDepartment of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. love857_qiwendeng@163.com.
Lei ZhangDepartment of Orthopaedics, Lanxi People's Hospital, Jinhua, Zhejiang, China. 303794458@qq.com.
Shukui WangCentral Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210006, China. shukwang@163.com.
Nanjing Medical University · CNNanjing Normal University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammation plays an integral role in carcinogenesis and tumor progression. Inflammatory response biomarkers have shown to be promising prognostic factors for improving the predictive accuracy in various cancers. The aim of this study is to investigate the prognostic significance of pre-operative neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR) in gastric cancer (GC).

methods389 patients who had undergone gastrectomy were enrolled from 2007 to 2009 in this study. NLR, dNLR, PLR and LMR were calculated from peripheral blood cell count taken at pre-operation. Receiver operating curve (ROC) was used to determine the optimal cut-off levels for these biomarkers. A predictive model or nomogram was established to predict prognosis for cancer-specific survival (CSS) and disease-free survival (DFS), and the predictive accuracy of the nomogram was determined by concordance index (c-index).

resultsThe median follow-up period was 24 months ranging from 3 months to 60 months. The optimal cut-off levels were 2.36 for NLR, 1.85 for dNLR, 132 for PLR and 4.95 for LMR by ROC curves analysis. Elevated NLR, dNLR and PLR were significantly associated with worse overall survival (OS), CSS and DFS, however, elevated LMR showed an adverse effect on worse OS, CSS and DFS. Multivariate analysis revealed that elevated dNLR was an independent factor for worse OS, and NLR was superior to dNLR, PLR and LMR in terms of hazard ratio (HR = 1.53, 95% CI = 1.11-2.11, P = 0.010), which was shown to be independent prognostic indicators for both CSS and DFS. Moreover, the nomogram could more accurately predict CSS (c-index: 0.89) and DFS (c-index: 0.84) in surgical GC patients.

conclusionsPre-operative NLR and dNLR may serve as potential prognostic biomarkers in patients with GC who underwent surgical resection. The proposed nomograms can be used for the prediction of CSS and DFS in patients with GC who have undergone gastrectomy.

Indexed as

Models, BiologicalAdultAgedAged, 80 and overBiomarkers, TumorDisease-Free SurvivalEndpoint DeterminationFemaleHumansInflammationKaplan-Meier EstimateLeukocyte CountMaleMiddle AgedMultivariate AnalysisPreoperative CareBiomarkers, Tumor

Identifiers

PMID25885254
PMCPMC4343078
OpenAlexW2121692731

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.