ArticleBMC psychiatry2015
Serum brain-derived neurotrophic factor levels and personality traits in patients with major depression.
Article in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Association between Val66Met polymorphisms in brain-derived neurotrophic factor gene and asthma risk: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Pooled it
- Circulating Growth Factors and Cytokines Correlate with Temperament and Character Dimensions in Adolescents with Mood Disorders.Brain sciences · 2025Article
- Sex steroid hormones in depressive disorders as a basis for new potential treatment strategies.Physiological research · 2022Review
- Association between brain-derived neurotropic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP) and psychiatric symptoms in medicated and unmedicated patients.BMC psychiatry · 2022Article
- MTORC1 signaling as a biomarker in major depressive disorder and its pharmacological modulation by novel rapid-acting antidepressants.Therapeutic advances in psychopharmacology · 2021Review
- Reduced serum BDNF levels are associated with the increased risk for developing MDD: a case-control study with or without antidepressant therapy.BMC research notes · 2020Article
- Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression.Neuropsychiatric disease and treatment · 2019Article
- Nursing interventions in depressed children with low serum levels of BDNF.Experimental and therapeutic medicine · 2017Article
- Effects of Endurance Exercise Modalities on Arterial Stiffness in Patients Suffering from Unipolar Depression: A Randomized Controlled Trial.Frontiers in psychiatry · 2017Article
- Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors. Previous studies have demonstrated lower serum BDNF levels in patients with major depressive disorder (MDD) and reported an association between BDNF levels and depression-related personality traits in healthy subjects. The aim of the present study was to explore for a possible association between peripheral BDNF levels and personality traits in patients with MDD.
methodsIn this cross-sectional study, a total of 123 inpatients with MDD (Diagnostic and Statistical Manual for Mental Disorders, 4th edition) at the Juntendo University Koshigaya Hospital were recruited. Serum levels of BDNF were measured. Personality traits were assessed using the 125-item short version of the Temperament and Character Inventory (TCI).
resultsMultiple regression analysis adjusted for age, sex, body mass index, dose of antidepressant, and depression severity showed that TCI Self-Directedness (SD) scores were negatively associated with serum BDNF levels (β = -0.23, p = 0.026).
conclusionsMDD patients who have low SD did not show the reduction in serum BDNF levels that is normally associated with depressive state. Our findings suggest that depression-related biological changes may not occur in these individuals.
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