ArticleMolecular pain2015
Alleviation of neuropathic pain by regulating T-type calcium channels in rat anterior cingulate cortex.
Article in Molecular pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Voltage-Gated Ion Channels in Neuropathic Pain Signaling.Life (Basel, Switzerland) · 2025Review
- Article
- Central and peripheral contributions of T-type calcium channels in pain.Molecular brain · 2022Review
- T-type CaMolecular pain · 2022Article
- Trigeminal neuropathic pain is alleviated by inhibition of CaChannels (Austin, Tex.) · 2021Article
- Role of the Anterior Cingulate Cortex in Translational Pain Research.Neuroscience bulletin · 2021Review
- The Effect of Optogenetic Inhibition of the Anterior Cingulate Cortex in Neuropathic Pain Following Sciatic Nerve Injury.Journal of molecular neuroscience : MN · 2021Article
- The Medial Prefrontal Cortex as a Central Hub for Mental Comorbidities Associated with Chronic Pain.International journal of molecular sciences · 2020Review
- Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats.Neuroscience bulletin · 2020Article
- Challenges of neuropathic pain: focus on diabetic neuropathy.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Role of Calcitonin Gene-Related Peptide in Nociceptive Modulationin Anterior Cingulate Cortex of Naïve Rats and Rats With Inflammatory Pain.Frontiers in pharmacology · 2020Article
- Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons.Scientific reports · 2019Article
- Neuropathic Pain: Central vs. Peripheral Mechanisms.Current pain and headache reports · 2017Review
- Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex of normal rats and rats with mononeuropathy.Scientific reports · 2017Article
- Article
- Optical inactivation of the anterior cingulate cortex modulate descending pain pathway in a rat model of trigeminal neuropathic pain created via chronic constriction injury of the infraorbital nerve.Journal of pain research · 2017Article
- Potentiation of synaptic transmission in Rat anterior cingulate cortex by chronic itch.Molecular brain · 2016Article
- Role of mu-opioid receptor in nociceptive modulation in anterior cingulate cortex of rats.Molecular painArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been demonstrated that administration of T-type calcium channel (TCC) inhibitors could relieve the neuropathic pain by intraperitoneally or intrathecally. TCCs are not only expressed in dorsal root ganglia or dorsal horn, but also in some of the pain associated brain regions. In the present study, we sought to investigate whether modulating TCCs in the anterior cingulate cortex (ACC) could alleviate the neuropathic pain.
results(1) Cav3.2 was up regulated in rat ACC after chronic constriction injury (CCI). (2) T-type calcium current intensity was increased in CCI animal model. (3) TCC inhibitor reduced miniature excitatory postsynaptic currents frequency of ACC neurons in CCI animal model. (4) TCC inhibitor suppressed the firing rate of ACC neurons in CCI animal model. (5) Both mechanical and thermal allodynia were partially relieved by ACC microinjection with TCC inhibitor.
conclusionsTCCs in the ACC may be contributing to the maintenance of neuropathic pain, and the neuropathic pain can be alleviated by inhibiting the neuronal activity of ACC through modulating the TCCs.
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