ArticleVeterinary research2015
Influence of the gestational stage on the clinical course, lesional development and parasite distribution in experimental ovine neosporosis.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Endogenous cathelicidin protects againstInfection and immunity · 2026Article
- Detection of Anti-Pathogens (Basel, Switzerland) · 2022Article
- Ovine Neosporosis: The Current Global Situation.Animals : an open access journal from MDPI · 2022Review
- A survey on Apicomplexa protozoa in sheep slaughtered for human consumption.Parasitology research · 2022Article
- Morphometric study of encephalic lesions in aborted bovine fetuses naturally infected by two subpopulations of Neospora caninum.Parasitology research · 2021Article
- In vivo and in vitro models show unexpected degrees of virulence among Toxoplasma gondii type II and III isolates from sheep.Veterinary research · 2021Article
- Article
- Isolation and genetic characterization of Toxoplasma gondii in Spanish sheep flocks.Parasites & vectors · 2020Article
- Isolation, Genotyping, and Mouse Virulence Characterization ofFrontiers in veterinary science · 2020Article
- Early Neospora caninum infection dynamics in cattle after inoculation at mid-gestation with high (Nc-Spain7)- or low (Nc-Spain1H)-virulence isolates.Veterinary research · 2019Article
- Effects of challenge dose and inoculation route of the virulent Neospora caninum Nc-Spain7 isolate in pregnant cattle at mid-gestation.Veterinary research · 2019Article
- Anti-Wrinkling and Anti-Melanogenic Effect ofInternational journal of molecular sciences · 2019Article
- Endogenous transplacental transmission of Neospora caninum during successive pregnancies across three generations of naturally infected sheep.Veterinary research · 2018Article
- Influence of dose and route of administration on the outcome of infection with the virulent Neospora caninum isolate Nc-Spain7 in pregnant sheep at mid-gestation.Veterinary research · 2018Article
- Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites.International journal for parasitology. Drugs and drug resistance · 2018Article
- Virulence in Mice of aFrontiers in cellular and infection microbiology · 2018Article
- Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends.Current topics in medicinal chemistry · 2018Review
- Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.Antimicrobial agents and chemotherapy · 2017Article
- Experimental ovine toxoplasmosis: influence of the gestational stage on the clinical course, lesion development and parasite distribution.Veterinary research · 2016Article
- Experimental caprine neosporosis: the influence of gestational stage on the outcome of infection.Veterinary research · 2016Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neospora caninum is considered one of the main causes of abortion in cattle, yet recent studies have also emphasised its relevance as an abortifacient in small ruminants. In order to gain deeper insight into the pathogenesis of ovine neosporosis, pregnant ewes were intravenously inoculated with 10(6) tachyzoites of the Nc-Spain7 isolate at days 40, 90 or 120 of gestation. Infection during the first term resulted in the death of all foetuses between days 19 and 21 post-infection, showing mainly necrotic lesions in foetal liver and the highest parasite DNA detection and burden in both placenta and foetal viscera. After infection at day 90, foetal death was also detected in all ewes, although later (34-48 days post-infection). In this group, lesions were mainly inflammatory. Foetal livers showed the lowest frequency of lesions, as well as the lowest parasite detection and burden. All ewes infected at day 120 delivered viable lambs, although 3 out of 9 showed weakness and recumbency. Neospora DNA was detected in all lambs but one, and parasite burden was similar to that observed in day 90 group. Lesions in this group showed more conspicuous infiltration of inflammatory cells and higher frequency in foetal brain and muscle when compared to both previous groups. These results highlight the crucial role that the stage of gestation plays on the course of ovine neosporosis, similar to that reported in bovine neosporosis, and open the doors to consider sheep as a valid model for exogenous transplacental transmission for ruminant neosporosis.
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