SynthesisPloS one2015
Association of hemostatic markers with atrial fibrillation: a meta-analysis and meta-regression.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04947657 (Correlation Of CoAGulation Biomarkers and Atrial Fibrillation Burden in Patients Post Catheter Ablation), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation Of CoAGulation Biomarkers and Atrial Fibrillation Burden in Patients Post Catheter Ablation: the COAG-AF Pilot Study
Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Rivaroxaban versus warfarin: differential effects on oxidative stress and fibrinolytic markers in atrial fibrillation.Frontiers in pharmacology · 2026Article
- The Association between Coagulation and Atrial Fibrillation.Biomedicines · 2024Review
- Article
- Mechanisms and Prediction of Ischemic Stroke in Atrial Fibrillation Patients.Journal of clinical medicine · 2023Review
- Cytotoxic CD8Cells · 2022Article
- The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation.The Journal of innovations in cardiac rhythm management · 2022Article
- Article
- Lifelong dietary omega-3 fatty acid suppresses thrombotic potential through gut microbiota alteration in aged mice.iScience · 2021Article
- The impact of volume substitution on post-operative atrial fibrillation.European journal of clinical investigation · 2021Article
- Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease.Frontiers in cardiovascular medicine · 2021Review
- Markers of coagulation and hemostatic activation aid in identifying causes of cryptogenic stroke.Neurology · 2020Article
- Paroxysmal Atrial Fibrillation: Insight Into the Intimate Mechanisms of Coagulation.Cardiology research · 2020Article
- Effects of Rivaroxaban on Biomarkers of Coagulation and Inflammation: A Post Hoc Analysis of the X-VeRT Trial.TH open : companion journal to thrombosis and haemostasis · 2020Article
- Paroxysmal atrial fibrillation: changes in factor VIII and von Willebrand factor impose early hypercoagulability.Archives of medical sciences. Atherosclerotic diseases · 2020Article
- Coagulation markers and echocardiography predict atrial fibrillation, malignancy or recurrent stroke after cryptogenic stroke.Medicine · 2018Observational
- Article
- Intracardiac Hemostasis and Fibrinolysis Parameters in Patients with Atrial Fibrillation.BioMed research international · 2017Article
- Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing evidence that indicates the presence of a prothrombotic state in atrial fibrillation (AF). However, the role of hemostatic markers in AF remains inconclusive.
methodsWe conducted a meta-analysis of observational studies to evaluate the association between hemostatic markers and AF. A meta-regression was performed to explore potential sources of heterogeneity.
resultsA total of 59 studies met our inclusion criteria for the meta-analysis. For platelet activation, increased circulating platelet factor-4, β-thromboglobulin (BTG) and P-selectin were significantly higher in AF cases compared with controls (standardized mean difference [SMD][95% confidence interval (CI)]: 1.72[0.96-2.49], 1.61[1.03-2.19] and 0.50[0.23-0.77], respectively). For coagulation activation, increased levels of plasma D-dimer, fibrinogen, thrombin-antithrombin, prothrombin fragment 1+2, and antithrombin-III were significantly associated with AF (SMD[95% CI]: 1.82[1.38-2.26], 0.72[0.55-0.89], 0.42[0.13-0.72], 1.00 [0.00-1.99] and 1.38[0.16-2.60], respectively). For fibrinolytic function, tissue-type plasminogen activator and plasminogen activator inhibitor-1 were significantly increased in AF cases compared with controls (SMD[95% CI]: 0.86[0.04-1.67] and 0.87[0.28-1.47], respectively) but the associations became nonsignificant after performing subgroup analysis by anticoagulants treatment status. For endothelial function, increased von Willebrand factor was significantly associated with AF (SMD, 0.79; 95% CI, 0.60-0.99); however, no association was observed for soluble thrombomodulin (SMD, 0.60; 95% CI, -0.13-1.33).
conclusionsIncreased circulating hemostatic factors (PF-4, BTG, P-selectin, D-dimer, fibrinogen, TAT, F1+2, AT- III, and vWf) are significantly associated with AF. Future research is necessary to elucidate the precise mechanism of the prothrombotic state and how hemostatic markers promote thromboembolism in AF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.