ArticleBirth defects research. Part A, Clinical and molecular teratology2015
Maternal exposures in the National Birth Defects Prevention Study: Time trends of selected exposures.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
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- Toxicology knowledge graph for structural birth defects.Communications medicine · 2023Article
- Characteristics of Individuals in the United States Who Used Opioids During Pregnancy.Journal of women's health (2002) · 2023Article
- Interaction of maternal medication use with ambient heat exposure on congenital heart defects in the National Birth Defects Prevention Study.Environmental research · 2022Article
- Cortical Cross-Frequency Coupling Is Affected byFrontiers in neuroscience · 2022Article
- Fifty Years of Research on Prenatal Substances: Lessons Learned for the Opioid Epidemic.Adversity and resilience science · 2020Article
- Survival of infants with spina bifida and the role of maternal prepregnancy body mass index.Birth defects research · 2019Article
- Adverse Pregnancy Outcomes: A Comparison of Risk Factors and Prevalence in Native and Migrant Mothers of Portuguese Generation XXI Birth Cohort.Journal of immigrant and minority health · 2019Article
- The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
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Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundOur objective was to describe time trends in selected pregnancy exposures in the National Birth Defects Prevention Study (NBDPS).
methodsWe analyzed data from the NBDPS, a multi-site case-control study of major birth defects, for mothers of live-born infants without birth defects (controls), with an expected date of delivery (EDD) from 1998 to 2011. Mothers from the 10 participating centers across the United States were interviewed by phone between 6 weeks and 2 years after the EDD. We focused on maternal race/ethnicity and five maternal risk factors: obesity, use of folic acid-containing multivitamins, opioid analgesics, selective serotonin reuptake inhibitors, and loratadine because of their prevalence of use and some reports of associations with major birth defects. Prevalence time trends were examined using the Kendall's τβ test statistic.
resultsThe exposure trend analysis included 11,724 control mothers with EDDs from 1998 to 2011. We observed a significant increase in obesity prevalence among control mothers, as well as use of selective serotonin reuptake inhibitors and loratadine. We also observed an increase in periconceptional use of folic acid-containing multivitamins. Some of the time trends varied by race/ethnicity. No remarkable trend in the overall use of opioid analgesics was observed. The racial/ethnic distribution of mothers changed slightly during the study period.
conclusionLong-term, population-based case-control studies continue to be an effective way to assess exposure-birth defects associations and provide guidance to health care providers. However, investigators examining rare outcomes covering many years of data collection need to be cognizant of time trends in exposures.
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