ArticlePloS one2015
Identification of glutathione S-transferase (GST) genes from a dark septate endophytic fungus (Exophiala pisciphila) and their expression patterns under varied metals stress.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Genome-wide identification of the GST reveals ZmGST1 enhances the resistance to Exserohilum turcicum in maize.BMC plant biology · 2026Article
- Genome-wide analysis of the glutathione S-transferase family inFrontiers in plant science · 2026Article
- Biosorption-based decontamination of mercury by Saccharomyces cerevisiae BY4741.Archives of microbiology · 2025Article
- Arsenic Stress Resistance in the Endophytic FungusJournal of fungi (Basel, Switzerland) · 2025Article
- Genome-wide identification and in silico analysis of GSTs reveals hormone mediated stress response in saffron.Frontiers in plant science · 2025Article
- Genome-wide identification, expression and functional analysis of glutathioneFrontiers in plant science · 2025Article
- Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics.Scientific reports · 2024Article
- Differential Strategies of Ectomycorrhizal Development betweenJournal of fungi (Basel, Switzerland) · 2024Article
- Incorporating omics-based tools into endophytic fungal research.Biotechnology notes (Amsterdam, Netherlands) · 2024Review
- Metabolism of plant-derived toxins from its insect host increases the success of the entomopathogenic fungus Beauveria bassiana.The ISME journal · 2023Article
- In-depth comparative transcriptome analysis of Purpureocillium sp. CB1 under cadmium stress.Applied microbiology and biotechnology · 2023Article
- Identification of glutathione metabolic genes from a dimorphic fungus Talaromyces marneffei and their gene expression patterns under different environmental conditions.Scientific reports · 2023Article
- Mapping and Identifying Candidate Genes Enabling Cadmium Accumulation inInternational journal of molecular sciences · 2023Article
- Enhanced mercury phytoremediation by Pseudomonodictys pantanalensis sp. nov. A73 and Westerdykella aquatica P71.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- FgSnt1 of the Set3 HDAC complex plays a key role in mediating the regulation of histone acetylation by the cAMP-PKA pathway in Fusarium graminearum.PLoS genetics · 2022Article
- Insights into the beneficial roles of dark septate endophytes in plants under challenging environment: resilience to biotic and abiotic stresses.World journal of microbiology & biotechnology · 2022Review
- Insight Into the Molecular Mechanisms Underpinning the Mycoremediation of Multiple Metals by Proteomic Technique.Frontiers in microbiology · 2022Article
- Differential response of physiology and metabolic response to drought stress in different sweetpotato cultivars.PloS one · 2022Article
- Rhizophagus proliferus genome sequence reiterates conservation of genetic traits in AM fungi, but predicts higher saprotrophic activity.Archives of microbiology · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferases (GSTs) compose a family of multifunctional enzymes that play important roles in the detoxification of xenobiotics and the oxidative stress response. In the present study, twenty four GST genes from the transcriptome of a metal-tolerant dark septate endophyte (DSE), Exophiala pisciphila, were identified based on sequence homology, and their responses to various heavy metal exposures were also analyzed. Phylogenetic analysis showed that the 24 GST genes from E. pisciphila (EpGSTs) were divided into eight distinct classes, including seven cytosolic classes and one mitochondrial metaxin 1-like class. Moreover, the variable expression patterns of these EpGSTs were observed under different heavy metal stresses at their effective concentrations for inhibiting growth by 50% (EC50). Lead (Pb) exposure caused the up-regulation of all EpGSTs, while cadmium (Cd), copper (Cu) and zinc (Zn) treatments led to the significant up-regulation of most of the EpGSTs (p < 0.05 to p < 0.001). Furthermore, although heavy metal-specific differences in performance were observed under various heavy metals in Escherichia coli BL21 (DE3) transformed with EpGSTN-31, the over-expression of this gene was able to enhance the heavy metal tolerance of the host cells. These results indicate that E. Pisciphila harbored a diverse of GST genes and the up-regulated EpGSTs are closely related to the heavy metal tolerance of E. pisciphila. The study represents the first investigation of the GST family in E. pisciphila and provides a primary interpretation of heavy metal detoxification for E. pisciphila.
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