Trial reportBMC public health2015
Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the Sun Exposure and Vitamin D Supplementation (SEDS) Study.
Trial report in BMC public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping the citation network on vitamin D research in Australia: a data-driven approach.Frontiers in medicine · 2023Pooled it
- Vitamin D in mucosal healing: therapeutic potential and current evidence in inflammatory bowel disease.Therapeutic advances in gastroenterology · 2026Review
- The Sunlight-Vitamin D Connection: Implications for Patient Outcomes in the Surgical Intensive Care Unit.Cureus · 2023Review
- Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases.Pharmacological reports : PR · 2023Review
- The Effects of Using the Sun Safe App on Sun Health Knowledge and Behaviors of Young Teenagers: Results of Pilot Intervention Studies.JMIR dermatology · 2022Article
- Sunlight, dietary habits, genetic polymorphisms and vitamin D deficiency in urban and rural infants of Bangladesh.Scientific reports · 2022Observational
- Serum Vitamin D Level and Risk of Community-Acquired Pneumonia: A Case-Control Study.Interdisciplinary perspectives on infectious diseases · 2021Article
- Systematic Review of the Effects of Ultraviolet Radiation on Markers of Metabolic Dysfunction.The Clinical biochemist. Reviews · 2019Review
- Vitamin D Deficiency, Skin Phototype, Sun Index, and Metabolic Risk Among Patients with High Rates of Sun Exposure Living in the Tropics.The Journal of clinical and aesthetic dermatology · 2018Article
- Prevalence of vitamin D insufficiency and evidence for disease prevention in the older population.Zeitschrift fur Gerontologie und Geriatrie · 2018Review
- Low levels of Vitamin D an emerging risk for cardiovascular diseases: A review.International journal of health sciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. METHODS/
designThe SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. DISCUSSION: This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention.
trial registrationAustralia New Zealand Clinical Trials Registry: ACTRN12613000290796 Registered 14 March 2013.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.