Evidence map›Paper›PMID 25884723›Full record

ArticleBMC nephrology2015

Renal resistive index as an indicator of the presence and severity of anemia and its future development in patients with hypertension.

Muneyoshi Tanimura, Kaoru Dohi, Masumi Matsuda, Yuichi Sato, Emiyo Sugiura, Naoto Kumagai, Shiro Nakamori, Tomomi Yamada, Naoki Fujimoto, Takashi Tanigawa and 3 more

Abstract readComparative Study
In one paragraph

Article in BMC nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muneyoshi TanimuraDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. m-tanimura@clin.medic.mie-u.ac.jp.
Kaoru DohiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. dohik@clin.medic.mie-u.ac.jp.
Masumi MatsudaCentral Clinical Laboratories, Mie University Hospital, Tsu, Japan. mandms@clin.medic.mie-u.ac.jp.
Yuichi SatoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. sato0726@clin.medic.mie-u.ac.jp.
Emiyo SugiuraDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. emyogw@gmail.com.
Naoto KumagaiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. kuma_cuma@yahoo.co.jp.
Shiro NakamoriDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. n-shiro@clin.medic.mie-u.ac.jp.
Tomomi YamadaDepartment of Translational Medical Science, Mie University Graduate School of Medicine, Tsu, Japan. t-yamada@doc.medic.mie-u.ac.jp.
Naoki FujimotoDepartment of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan. naokifujimo@hotmail.com.
Takashi TanigawaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. t-tanigw@clin.medic.mie-u.ac.jp.
Norikazu YamadaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. n-yamada@clin.medic.mie-u.ac.jp.
Mashio NakamuraDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. mashio@clin.medic.mie-u.ac.jp.
Masaaki ItoDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. mitoka@clin.medic.mie-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe examined whether renal resistive index (RI), a simple index of renal vascular resistance, is associated with the presence and severity of anemia, and can predict the future development of anemia in patients with hypertension.

methodsWe retrospectively examined 175 patients with hypertension (mean age 67 ± 11 years, 32-85 years, 134 males) who underwent renal ultrasonography. Anemia was defined as a reduction in the concentration of hemoglobin <13.0 g/dL for men and <12.0 g/dL for women. Renal RI was measured in the interlobar arteries.

resultsAnemia was present in 37% of men and 34% of women. The mean estimated glomerular filtration rate (eGFR) was 58 ± 23 ml/min/1.73 m(2) (median: 56 ml/min/1.73 m(2), range: 16-168 ml/min/1.73 m(2)) and the mean renal RI was 0.70 ± 0.09 (median: 0.70, range: 0.45-0.92). Proteinuria was present in 29% of patients. Both eGFR and renal RI correlated significantly with hemoglobin levels. In the stepwise multivariate linear regression analysis, renal RI was associated with hemoglobin levels independently of potential confounders including eGFR. During the follow-up period (median: 959 days, range: 7-3595 days), Kaplan-Meier curves demonstrated that patients with renal RI above the median value had a higher incidence of the future development of anemia than other patients. Cox regression analysis showed that renal RI (hazard ratio 1.18, 95% CI 1.02-1.37 per 0.05 rises in renal RI, p =0.03) and the presence of proteinuria were (hazard ratio 1.80, 95% CI 1.08-3.01, p =0.03) were independently associated with the future development of anemia after correcting for confounding factors.

conclusionsMeasurement of renal RI can be useful for elucidating the pathogenesis of anemia and for inferring its potential risk in patients with hypertension.

Indexed as

AdultAgedAged, 80 and overAge FactorsAnemiaCohort StudiesDisease ProgressionFemaleFollow-Up StudiesGlomerular Filtration RateHemoglobinsHumansHypertensionJapanKaplan-Meier EstimateLinear ModelsHemoglobins

Identifiers

PMID25884723
PMCPMC4393622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.