Evidence map›Paper›PMID 25884678›Full record

ArticleBMC public health2015

Cancer incidence and mortality for all causes in HIV-infected patients over a quarter century: a multicentre cohort study.

Elena Raffetti, Laura Albini, Daria Gotti, Daniela Segala, Franco Maggiolo, Elisa di Filippo, Annalisa Saracino, Nicoletta Ladisa, Giuseppe Lapadula, Chiara Fornabaio and 7 more

Abstract readMulticenter Study
In one paragraph

Article in BMC public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Weight gain, obesity, and the impact of lifestyle factors among people living with HIV: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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  4. Thyroid cancer risk in people living with HIV: a systematic review and meta-analysis of global population-based registry studies.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elena RaffettiUnit of Hygiene, Epidemiology and Public Health, University of Brescia, Brescia, Italy. e.raffetti@unibs.it.
Laura AlbiniUniversity Division of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy. lauralbini@gmail.com.
Daria GottiUniversity Division of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy. daria.gotti@gmail.com.
Daniela SegalaDepartment of Infectious Diseases of Nuovo Polo Ospedaliero S.Anna di Cona, Ferrara, Italy. d.segala@yahoo.it.
Franco MaggioloDepartment of Infectious Diseases of Papa Giovanni XXIII Hospital, Bergamo, Italy. franco31556@hotmail.com.
Elisa di FilippoDepartment of Infectious Diseases of Papa Giovanni XXIII Hospital, Bergamo, Italy. elisadifilippo@libero.it.
Annalisa SaracinoDepartment of Infectious Diseases of Polyclinic of Bari, University of Bari, Bari, Italy. a.saracino@medicina.unifg.it.
Nicoletta LadisaDepartment of Infectious Diseases of Polyclinic of Bari, University of Bari, Bari, Italy. n.ladisa@hotmail.com.
Giuseppe LapadulaDepartment of Infectious Diseases, San Gerardo de' Tintori" Hospital, Monza, Italy. giuseppe.lapadula@gmail.com.
Chiara FornabaioClinic of Infectious Diseases of Istituti Ospitalieri of Cremona, Cremona, Italy. chifor76@yahoo.it.
Filippo CastelnuovoHospital Division of Infectious and Tropical Diseases, Spedali Civili Hospital, Brescia, Italy. filippo.castel@tin.it.
Salvatore CasariUniversity Division of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy. s.casari@infettivibrescia.it.
Massimiliano FabbianiInstitute of Clinical Infectious Diseases of Polyclinic A. Gemelli, University of Sacred Heart, Rome, Italy. massifab@alice.it.
Piera PierottiDepartment of Infectious Diseases of SM, Annunziata Hospital of Florence, Florence, Italy. piera.pierotti@asf.toscana.it.
Francesco DonatoUnit of Hygiene, Epidemiology and Public Health, University of Brescia, Brescia, Italy. francesco.donato@unibs.it.
Eugenia Quiros-RoldanUniversity Division of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy. eugeniaquiros@yahoo.it.
MASTER Cohort

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to assess cancer incidence and mortality for all-causes and factors related to risk of death in an Italian cohort of HIV infected unselected patients as compared to the general population.

methodsWe conducted a retrospective (1986-2012) cohort study on 16 268 HIV infected patients enrolled in the MASTER cohort. The standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were computed using cancer incidence rates of Italian Cancer Registries and official national data for overall mortality. The risk factors for death from all causes were assessed using Poisson regression models.

results1,195 cancer cases were diagnosed from 1986 to 2012: 700 AIDS-defining-cancers (ADCs) and 495 non-AIDS-defining-cancers (NADCs). ADC incidence was much higher than the Italian population (SIR = 30.8, 95% confidence interval 27.9-34.0) whereas NADC incidence was similar to the general population (SIR = 0.9, 95% CI 0.8-1.1). The SMR for all causes was 11.6 (11.1-12.0) in the period, and it decreased over time, mainly after 1996, up to 3.53 (2.5-4.8) in 2012. Male gender, year of enrolment before 1993, older age at enrolment, intravenous drug use, low CD4 cell count, AIDS event, cancer occurrence and the absence of antiretroviral therapy were all associated independently with risk of death.

conclusionsIn HIV infected patients, ADC but not NADC incidence rates were higher than the general population. Although overall mortality in HIV infected subjects decreased over time, it is about three-fold higher than the general population at present.

Indexed as

Acquired Immunodeficiency SyndromeAdolescentAdultAgedAge FactorsAnti-Retroviral AgentsCD4 Lymphocyte CountCohort StudiesFemaleHIV InfectionsHumansIncidenceItalyMaleMiddle AgedNeoplasmsAnti-Retroviral Agents

Identifiers

PMID25884678
PMCPMC4364101

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.