ArticleBMC oral health2015
Pathological periodontal pockets are associated with raised diastolic blood pressure in obese adolescents.
Article in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis.BMC oral health · 2017Pooled it
- Dysbiotic Microbiome-Metabolome Axis in Childhood Obesity and Metabolic Syndrome.Journal of dental research · 2025Article
- Association of chronic periodontitis in a broad spectrum of cardiometabolic syndrome: A minireview.World journal of cardiology · 2025Review
- Bidirectional Association between Periodontitis and Thyroid Disease: A Scoping Review.International journal of environmental research and public health · 2024Article
- Pediatric obesity-Long-term consequences and effect of weight loss.Journal of internal medicine · 2022Review
- Cross-sectional study on the association of periodontitis with arterial hypertension in the Hamburg City Health Study.European journal of medical research · 2022Article
- Systemic Inflammation, Oxidative Stress and Cardiovascular Health in Children and Adolescents: A Systematic Review.Antioxidants (Basel, Switzerland) · 2022Review
- Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases.Diagnostics (Basel, Switzerland) · 2021Review
- Association Between Arterial Hypertension and Periodontal Status in Morbidly Obese Patients Who Are Candidates for Bariatric Surgery.International dental journal · 2021Article
- Childhood Oral Infections Associate with Adulthood Metabolic Syndrome: A Longitudinal Cohort Study.Journal of dental research · 2020Article
- Relationship between hypothyroidism and periodontitis: A scoping review.Clinical and experimental dental research · 2020Article
- Salivary Microbiological and Gingival Health Status Evaluation of Adolescents With Overweight and Obesity: A Cluster Analysis.Frontiers in pediatrics · 2020Article
- Association Between Periodontal Disease and Atherosclerotic Cardiovascular Diseases: Revisited.Frontiers in cardiovascular medicine · 2020Review
- Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction.British journal of pharmacology · 2019Article
- Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood.JAMA network open · 2019Article
- Stress-related hormones in association with periodontal condition in adolescents-results of the epidemiologic LIFE Child study.Clinical oral investigations · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity, a well-known risk factor for developing cardiovascular disease (CVD), is associated with chronic periodontitis in adults. This cross-sectional pilot study on obese adolescents was designed to investigate whether periodontal disease in terms of pathological periodontal pockets is associated with raised blood pressure and other risk markers for CVD.
methodsThe study included 75 obese subjects between 12 to 18 years of age, mean 14.5. Subjects answered a questionnaire regarding health, oral hygiene habits and sociodemographic factors. A clinical examination included Visible Plaque Index (VPI %), Gingival inflammation (BOP %) and the occurrence of pathological pockets exceeding 4 mm (PD ≥ 4 mm). Blood serum were collected and analyzed. The systolic and diastolic blood pressures were registered.
resultsAdolescents with pathological periodontal pockets (PD ≥ 4 mm; n = 14) had significantly higher BOP >25% (P = 0.002), higher diastolic blood pressure (P = 0.008), higher levels of Interleukin (IL)-6 (P < 0.001), Leptin (P = 0.018), Macrophage Chemoattractant Protein-1 (MCP-1) (P = 0.049) and thyroid stimulating hormone (TSH) (P = 0.004) in blood serum compared with subjects without pathological periodontal pockets (PD ≥ 4 mm; n = 61). The bivariate linear regression analysis demonstrated that PD ≥ 4 mm (P = 0.008) and systolic blood pressure (P < 0.001) were significantly associated with the dependent variable "diastolic blood pressure". The association between PD ≥ 4 mm and diastolic blood pressure remained significant (P = 0.006) even after adjusting for potential confounders BMI-sds, age, gender, mother's country of birth, BOP >25%, IL-6, IL-8, Leptin, MCP-1, TSH and total cholesterol in the multiple regression analysis.
conclusionIn conclusion, this study indicates an association between pathological periodontal pockets and diastolic blood pressure in obese adolescents. The association was unaffected by other risk markers for cardiovascular events or periodontal disease. The results call for collaboration between pediatric dentists and medical physicians in preventing obesity development and its associated disorders.
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