Evidence map›Paper›PMID 25884547›Full record

ArticleBMC cancer2015

Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma.

Curtis J Henry, Rebecca L Sedjo, Andrii Rozhok, Jennifer Salstrom, Dennis Ahnen, Theodore R Levin, Ralph D'Agostino, Steven Haffner, James DeGregori, Tim Byers

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Curtis J HenryDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, MS 8010, Aurora, CO, USA, 80045. Curtis.Henry@ucdenver.edu.
Rebecca L SedjoDepartment of Community and Behavioral Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, 13001 East 17th Place, MS F519, Aurora, CO, USA, 80045. Rebecca.Sedjo@ucdenver.edu.
Andrii RozhokDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, MS 8010, Aurora, CO, USA, 80045. Andrii.Rozhok@ucdenver.edu.
Jennifer SalstromDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, MS 8010, Aurora, CO, USA, 80045. Jennifer.Salstrom@childrenscolorado.org.
Dennis AhnenDepartment of Gastroenterology and Hepatology, University of Colorado Denver, Aurora, CO, USA, 80045. Dennis.Ahnen@ucdenver.edu.
Theodore R LevinKaiser Permanente Division of Research, 2000 Broadway, Oakland, CA, USA, 94612. Theodore.Levin@kp.org.
Ralph D'AgostinoDepartment of Biostatistical Sciences, Section on Biostatistics, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA, 27157. Rdagosti@wakehealth.edu.
Steven HaffnerUniversity of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX, USA, 78229. Traffic15@satx.rr.com.
James DeGregoriDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, MS 8010, Aurora, CO, USA, 80045. James.DeGregori@ucdenver.edu.
Tim ByersDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, 13001 East 17th Place, B119 Building 500, Room W3122, Aurora, CO, USA, 80045. Tim.Byers@ucdenver.edu.
University of Colorado Anschutz Medical Campus · USColorado School of Public Health · USKaiser Permanente · USNational Jewish Health · USThe University of Texas Health Science Center at San Antonio · USUniversity of Colorado Denver · USWake Forest University · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Aging-associated alterations in adaptive landscapes and the evolution of leukemiaR01CA180175 · NCI · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2013 to 2018
$1.8M
Insulin Resistance and Adenomas of the ColorectumR01CA088008 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B. · 2001 to 2003
$1.0M
Insulin Resistance and Adenomas of the ColorectumR01CA088007 · NCI · UNIVERSITY OF COLORADO DENVER · PI BYERS, TIM E · 2001 to 2003
$999k
Dissecting the relationship between declining lymphoid progenitor fitness and agiK01CA160798 · NCI · UNIVERSITY OF COLORADO DENVER · PI HENRY, CURTIS JAMES · 2012 to 2016
$441k
NCATS NIH HHS UL1 TR001082NCI NIH HHS 1R01CA180175NCI NIH HHS 1R01CA88007NCI NIH HHS 1R01CA88008NCI NIH HHS 5K01CA160798-02NCI NIH HHS K01 CA160798NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA088007NCI NIH HHS R01 CA088008NCI NIH HHS R01 CA180175NCRR NIH HHS UL1 RR025780
6 · The paper itself

Abstract

backgroundInflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, such as the formation of adenomas, is unclear.

methodsUsing the Milliplex® MAP Human Cytokine/ Chemokine Magnetic Bead Panel Immunoassay, serum cytokine and chemokine profiles were assayed among participants without an adenoma (n = 97) and those with an adenoma (n = 97) enrolled in the NCI-funded Insulin Resistance Atherosclerosis Colon Study. The concentrations of interleukin-10 (IL-10), IL-1β, IL-6, IL-17A, IL-2, IL-4, IL-7, IL-12(p70), interferon-γ (IFN-γ), macrophage chemoattractant protein-1 (MCP-1), regulated on activation, normal T cell expressed and secreted (RANTES), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), granulocyte macrophage colony-stimulating factor (GM-CSF), and macrophage inflammatory protein-1β (MIP-1β) were determined. Multiple logistic regression analyses were used to evaluate the association between adenoma prevalence and cytokine levels.

resultsThe presence of colorectal adenomas was not associated with significant increases in the systemic levels of proinflammatory (TNF-α, IL-6, IL-1β) or T-cell polarizing (IL-12, IL-2, IL-10, IL-4, IL-17, IFN-γ) cytokines. Furthermore, MCP-1 and RANTES levels were equivalent in the serum of study participants with and without adenomas.

conclusionsThese findings suggest colorectal adenoma prevalence may not be associated with significant alterations in systemic inflammation.

Indexed as

AdenomaAgedBiomarkers, TumorCase-Control StudiesCohort StudiesColorectal NeoplasmsCytokinesFemaleHumansInflammation MediatorsMaleMiddle AgedProspective StudiesBiomarkers, TumorCytokinesInflammation Mediators

Identifiers

PMID25884547
PMCPMC4359784
OpenAlexW2075639444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.