Evidence map›Paper›PMID 25884546›Full record

ArticleBMC neurology2015

Stroke patients' knowledge about cardiovascular family history - the Norwegian Stroke in the Young Study (NOR-SYS).

Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Geir Egil Eide, Lars Thomassen, Halvor Naess, Ulrike Waje-Andreassen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01597453 (NOR-SYS), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01597453 naactive not recruitingnot on this map

NOR-SYS: The Norwegian Stroke in the Young Study Young Ischemic Stroke and Family Risk Factors

TypeinterventionalSponsorHaukeland University HospitalRan2010 to 2030Enrolled1,062ConditionsDeath, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery DiseaseArmsLifestyle counseling
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Halvor ØygardenDepartment of Clinical Medicine, University of Bergen, Bergen, Norway. havy@helse-bergen.no.
Annette FrommDepartment of Clinical Medicine, University of Bergen, Bergen, Norway. atfm@helse-bergen.no.
Kristin Modalsli SandDepartment of Clinical Medicine, University of Bergen, Bergen, Norway. kssa@helse-bergen.no.
Geir Egil EideCentre for Clinical Research, Haukeland University Hospital, Bergen, Norway. geir.egil.eide@helse-bergen.no.
Lars ThomassenDepartment of Clinical Medicine, University of Bergen, Bergen, Norway. ltho@haukeland.no.
Halvor NaessDepartment of Clinical Medicine, University of Bergen, Bergen, Norway. haln@helse-bergen.no.
Ulrike Waje-AndreassenDepartment of Neurology, Haukeland University Hospital, N-5021, Bergen, Norway. uwan@helse-bergen.no.
University of Bergen · NOHaukeland University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFamily history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic stroke patients' knowledge on FH of stroke, CAD, and peripheral artery disease (PAD) with a special regard to sex differences.

methodsFrom September 2010 to February 2014, all ischemic stroke patients aged 15-60 years were prospectively included in the Norwegian Stroke in the Young Study (NOR-SYS). FH of stroke, CAD and PAD in offspring, siblings, parents, and grandparents was assessed using a standardized face-to-face interview. In addition to 'yes' and 'no', the optional reply 'don't know' was included to improve accuracy. McNemar's test was used to compare paired proportions, i.e. FH in male vs. female relatives. Multiple logistic regression analyses were used to test the influence of patient sex on FH reporting and to adjust for possible confounding factors.

resultsAltogether 257 patients were included. Mean age was 49.5 years and 68.1% were males. FH of cardiovascular disease was reported by 59% of patients. When asked about FH of stroke, 48 (18.7%) and 46 (17.9%) patients reported yes, whereas 17 (6.6%) and 9 (3.5%) reported 'don't know' regarding father and mother respectively, similarly patients reported 'don't know' regarding 117 (45.5%) paternal vs. 83 (32.4%) maternal grandmothers (p < 0.001). Female patients reported less 'don't know' and were more likely to report a positive cardiovascular FH than males (OR: 3.4; 95% CI: 1.5 to 7.7; p = 0.004). Patients had more detailed knowledge about CAD than stroke in fathers (p < 0.001), mothers (p < 0.001) and siblings (p = 0.01).

conclusionsYoung and middle-aged stroke patients reported a high FH burden of cardiovascular disease. Females are more likely to report a positive FH than males. Detailed knowledge on FH was best for CAD. Our results suggest sex has a big impact on FH knowledge. Females have more knowledge of FH than males and knowledge is better for relatives with a female than male linkage. CLINICAL

trial registrationhttp://www.clinicaltrials.gov , unique identifier: NCT01597453 .

Indexed as

Coronary Artery DiseaseFamilyHealth Knowledge, Attitudes, PracticeStrokeAdolescentAdultCardiovascular DiseasesCohort StudiesFathersFemaleHumansMaleMiddle AgedMothersNorwayProspective Studies

Identifiers

PMID25884546
PMCPMC4359475
OpenAlexW1978367185

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.