ArticleMarine drugs2015
New prenylated aeruginosin, microphycin, anabaenopeptin and micropeptin analogues from a Microcystis bloom material collected in Kibbutz Kfar Blum, Israel.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Discovery of Suomilide and Cyanopeptolin Analogues byJournal of natural products · 2026Article
- Secondary metabolism ofApplied and environmental microbiology · 2026Review
- Anabaenopeptin B Chlorination Degradation By-Products Retain Potent Carboxypeptidase B Inhibition.ACS ES&T water · 2025Article
- Chemical diversity of cyanobacterial natural products.Natural product reports · 2025Review
- Biosynthesis of guanidine-containing natural products in cyanobacteria.Journal of industrial microbiology & biotechnology · 2024Review
- The Chemistry of Phytoplankton.Chemical reviews · 2024Review
- Aeruginosin 525 (AER525) from CyanobacteriumMarine drugs · 2024Article
- High Structural Diversity of Aeruginosins in Bloom-Forming Cyanobacteria of the GenusMarine drugs · 2023Article
- Structural Diversity and Biological Activity of Cyanopeptolins Produced byMarine drugs · 2023Article
- Anabaenopeptins fromInternational journal of environmental research and public health · 2022Article
- Article
- Anabaenopeptins: What We Know So Far.Toxins · 2021Review
- Seasonal Dynamics Are the Major Driver of Microbial Diversity and Composition in Intensive Freshwater Aquaculture.Frontiers in microbiology · 2021Article
- Article
- Natural Products from Cyanobacteria: Focus on Beneficial Activities.Marine drugs · 2019Review
- Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera:Frontiers in chemistry · 2019Review
- Cyanopeptolins with Trypsin and Chymotrypsin Inhibitory Activity from the CyanobacteriumMarine drugs · 2018Article
- Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea.Journal of natural products · 2018Article
- Inhibitors of Serine Proteases from a Microcystis sp. Bloom Material Collected from Timurim Reservoir, Israel.Marine drugs · 2017Article
- Cyanobacterial Toxic and Bioactive Peptides in Freshwater Bodies of Greece: Concentrations, Occurrence Patterns, and Implications for Human Health.Marine drugs · 2015Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thirteen new and eighteen known natural products were isolated from a bloom material of an assembly of various Microcystis spp. collected in November, 2008, from a commercial fishpond near Kibbutz Kfar Blum, the Jordan Valley, Israel. The new natural products included the prenylated aeruginosin KB676 (1), microphycin KB921 (2), anabaenopeptins KB906 (3) and KB899 (4) and micropeptins KB928 (5), KB956 (6), KB970A (7), KB970B (8), KB984 (9), KB970C (10), KB1048 (11), KB992 (12) and KB1046 (13). Their structures were elucidated primarily by interpretation of their 1D and 2D nuclear magnetic resonance spectra and high-resolution mass spectrometry. Marfey's and chiral-phase high performance liquid chromatography methods were used to determine the absolute configurations of their chiral centers. Aeruginosin KB676 (1) contains the rare (2S,3aS,6S,7aS)-Choi and is the first prenylated aeruginosin derivative described in the literature. Compounds 1 and 5-11 inhibited trypsin with sub-μM IC50s, while Compounds 11-13 inhibited chymotrypsin with sub-μM IC50s. The structures and biological activities of the new natural products and our procedures of dereplication are described.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.