ArticleParasites & vectors2015
Evidence for a specific host-endosymbiont relationship between 'Rickettsia sp. genotype RF2125' and Ctenocephalides felis orientis infesting dogs in India.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Ticks and fleas of the critically endangered mountain pygmy-possum (International journal for parasitology. Parasites and wildlife · 2026Article
- The Comparative Study for Detection of Canine Vector-Borne Pathogens Between Companion and Stray Dogs in Bangkok and Vicinities, Thailand.Pathogens (Basel, Switzerland) · 2026Article
- Identification of Ctenocephalides felis felis and the detection and characterization of associated Wolbachia endosymbiont in Pakistan.BMC veterinary research · 2026Article
- Identification and pathogen screening of ectoparasites from companion animals in urban Vientiane, Lao PDR.PLoS neglected tropical diseases · 2025Article
- Molecular detection and genetic characterization of hemotropic mycoplasmas in goats and fleas from Thailand.Scientific reports · 2024Article
- Differentiation of Synanthropic Fleas from Andalusia (Spain) through Geometric Morphometrics Analysis.Animals : an open access journal from MDPI · 2024Article
- A Review of Rickettsial Diseases Other Than Scrub Typhus in India.Tropical medicine and infectious disease · 2023Review
- Fleas from the Silk Road in Central Asia: identification of Ctenocephalides canis and Ctenocephalides orientis on owned dogs in Uzbekistan using molecular identification and geometric morphometrics.Parasites & vectors · 2022Article
- Population genetics and genetic variation of Ctenocephalides felis and Pulex irritans in China by analysis of nuclear and mitochondrial genes.Parasites & vectors · 2022Article
- Amplicon-Based Next Generation Sequencing for Rapid Identification ofPathogens (Basel, Switzerland) · 2021Article
- Metagenomic analysis of human-biting cat fleas in urban northeastern United States of America reveals an emerging zoonotic pathogen.Scientific reports · 2020Article
- Molecular detection of pathogens in ticks and fleas collected from companion dogs and cats in East and Southeast Asia.Parasites & vectors · 2020Article
- Zoonotic Vectorborne Pathogens and Ectoparasites of Dogs and Cats in Eastern and Southeast Asia.Emerging infectious diseases · 2020Article
- Survey of Rickettsia spp. and Orientia tsutsugamushi Pathogens Found in Animal Vectors (Ticks, Fleas, Chiggers) in Bangkaew District, Phatthalung Province, Thailand.The Korean journal of parasitology · 2019Article
- Ctenocephalides canis is the dominant flea species of dogs in the Republic of Korea.Parasites & vectors · 2018Article
- The epidemiology of Rickettsia felis infecting fleas of companion animals in eastern Australia.Parasites & vectors · 2018Article
- Reptile-associated Borrelia species in the goanna tick (Bothriocroton undatum) from Sydney, Australia.Parasites & vectors · 2017Article
- The Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review.Insects · 2017Review
- Canine vector-borne pathogens in semi-domesticated dogs residing in northern Cambodia.Parasites & vectors · 2016Article
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFleas of the genus Ctenocephalides serve as vectors for a number of rickettsial zoonoses, including Rickettsia felis. There are currently no published reports of the presence and distribution of R. felis in India, however, the ubiquitous distribution of its vector Ctenocephalides felis, makes it possible that the pathogen is endemic to the region. This study investigates the occurrence of Rickettsia spp. infection in various subspecies of C. felis infesting dogs from urban areas of Mumbai, Delhi and Rajasthan in India.
methodsIndividual fleas collected off 77 stray dogs from Mumbai, Delhi and Rajasthan were screened for Rickettsia spp. by a conventional PCR targeting the ompB gene. Further genetic characterisation of Rickettsia-positive fleas was carried out using nested PCR and phylogenetic analysis of partial DNA sequences of the gltA and ompA genes. Ctenocephalides spp. were morphologically and genetically identified by PCR targeting a fragment of cox1 gene.
resultsOverall, 56/77 fleas (72.7%), including 22/24 (91.7%) from Delhi, 32/44 (72.7%) from Mumbai and 2/9 (22.2%) from Rajasthan were positive for Rickettsia DNA at the ompB gene. Sequences of gltA fragments confirmed the amplification of Rickettsia sp. genotype RF2125. The ompA gene of Rickettsia sp. genotype RF2125 was characterised for the first time and shown 96% identical to R. felis. Three species of Ctenocephalides were identified, with the Ctenocephalides felis orientis being the dominant flea species (69/77; 89.6%) in India, followed by Ctenocephalides felis felis (8/77; 10.4%).
conclusionsHigh occurrence of Rickettsia sp. genotype RF2125 in C. felis orientis and the absence of R. felis suggests a specific vector-endosymbiont adaptation and coevolution of the Rickettsia felis-like sp. within subspecies of C. felis.
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