ArticleBMC genomics2015
Molecular insights into land snail neuropeptides through transcriptome and comparative gene analysis.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- From neuropeptides to toxins: illuminating the origins of venom complexity in cone snails.Molecular biology and evolution · 2026Article
- From Neuropeptides to Toxins: Illuminating the Origins of Venom Complexity in Cone Snails.bioRxiv : the preprint server for biology · 2025Article
- Analysis of rhodopsin G protein-coupled receptor orthologs reveals semiochemical peptides for parasite (Schistosoma mansoni) and host (Biomphalaria glabrata) interplay.Scientific reports · 2022Article
- Nemertean, Brachiopod, and Phoronid Neuropeptidomics Reveals Ancestral Spiralian Signaling Systems.Molecular biology and evolution · 2021Article
- Transcriptome Profiling of the Pacific OysterMarine drugs · 2021Article
- Development and Interrogation of a Transcriptomic Resource for the Giant Triton Snail (Charonia tritonis).Marine biotechnology (New York, N.Y.) · 2021Article
- Evolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect Allatostatins.Frontiers in endocrinology · 2021Article
- Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs.Frontiers in physiology · 2021Article
- Neural Ganglia Transcriptome and Peptidome Associated with Sexual Maturation in Female Pacific Abalone (Genes · 2019Article
- Extensive conservation of the proneuropeptide and peptide prohormone complement in mollusks.Scientific reports · 2019Article
- A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae ofFrontiers in zoology · 2019Article
- Identification and Characterization of Neuropeptides by Transcriptome and Proteome Analyses in a Bivalve MolluscFrontiers in genetics · 2018Article
- Do terrestrial gastropods use olfactory cues to locate and select food actively?Invertebrate neuroscience : IN · 2017Review
- Copy number alteration of neuropeptides and receptors in multiple cancers.Scientific reports · 2017Article
- The transcriptome of a "sleeping" invader: de novo assembly and annotation of the transcriptome of aestivating Cornu aspersum.BMC genomics · 2017Article
- Changes in the neuropeptide content of Biomphalaria ganglia nervous system following Schistosoma infection.Parasites & vectors · 2017Article
- Hormone-like peptides in the venoms of marine cone snails.General and comparative endocrinology · 2017Article
- Comparative profiling of hepatopancreas transcriptomes in satiated and starving Pomacea canaliculata.BMC genetics · 2017Article
- A "Love" Dart Allohormone Identified in the Mucous Glands of Hermaphroditic Land Snails.The Journal of biological chemistry · 2016Article
- De novo Transcriptome Generation and Annotation for Two Korean Endemic Land Snails, Aegista chejuensis and Aegista quelpartensis, Using Illumina Paired-End Sequencing Technology.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSnails belong to the molluscan class Gastropoda, which inhabit land, freshwater and marine environments. Several land snail species, including Theba pisana, are crop pests of major concern, causing extensive damage to agriculture and horticulture. A deeper understanding of their molecular biology is necessary in order to develop methods to manipulate land snail populations.
resultsThe present study used in silico gene data mining of T. pisana tissue transcriptomes to predict 24,920 central nervous system (CNS) proteins, 37,661 foot muscle proteins and 40,766 hepatopancreas proteins, which together have 5,236 unique protein functional domains. Neuropeptides, metabolic enzymes and epiphragmin genes dominated expression within the CNS, hepatopancreas and muscle, respectively. Further investigation of the CNS transcriptome demonstrated that it might contain as many as 5,504 genes that encode for proteins destined for extracellular secretion. Neuropeptides form an important class of cell-cell messengers that control or influence various complex metabolic events. A total of 35 full-length neuropeptide genes were abundantly expressed within T. pisana CNS, encoding precursors that release molluscan-type bioactive neuropeptide products. These included achatin, allototropin, conopressin, elevenin, FMRFamide, LFRFamide, LRFNVamide, myomodulins, neurokinin Y, PKYMDT, PXFVamide, sCAPamides and several insulin-like peptides. Liquid chromatography-mass spectrometry of neural ganglia confirmed the presence of many of these neuropeptides.
conclusionsOur results provide the most comprehensive picture of the molecular genes and proteins associated with land snail functioning, including the repertoire of neuropeptides that likely play significant roles in neuroendocrine signalling. This information has the potential to expedite the study of molluscan metabolism and potentially stimulate advances in the biological control of land snail pest species.
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