Evidence map›Paper›PMID 25884390›Full record

Trial reportReproductive biology and endocrinology : RB&E2015

Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old.

Massimo Tartagni, Maria V Cicinelli, Domenico Baldini, Mario V Tartagni, Hala Alrasheed, Maria A DeSalvia, Giuseppe Loverro, Monica Montagnani

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  11. Randomized Controlled Study of the Effects of DHEA on the Outcome of IVF in Endometriosis.Evidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Massimo TartagniDepartment of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, Italy. massimo.tartagni@uniba.it.
Maria V CicinelliCentro di Fecondazione Medicalmente Assistita MoMò Fertilife, Bisceglie, Italy. mavi_cici@hotmail.it.
Domenico BaldiniCentro di Fecondazione Medicalmente Assistita MoMò Fertilife, Bisceglie, Italy. dbaldini@libero.it.
Mario V TartagniCentro di Fecondazione Medicalmente Assistita MoMò Fertilife, Bisceglie, Italy. mv.tartagni@libero.it.
Hala AlrasheedCentro di Fecondazione Medicalmente Assistita MoMò Fertilife, Bisceglie, Italy. H.ra@libero.it.
Maria A DeSalviaDepartment of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, Italy. mariaantonietta.desalvia@uniba.it.
Giuseppe LoverroDepartment of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, Italy. giuseppe.loverro@uniba.it.
Monica MontagnaniDepartment of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari "Aldo Moro", Bari, Italy. monica.montagnani@uniba.it.
Ospedale degli Infermi · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith infertility populations rapidly aging, treatments improving pregnancy chances assume increasing clinical importance. Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy rates and lower miscarriage rates in women with diminished ovarian function. This study was planned to evaluate whether pretreatment with DHEA may improve in vitro fertilization (IVF) parameters and pregnancy outcomes in infertile women with advanced reproductive age and normal ovarian reserve.

methodsIn this double-blind, randomized, placebo-controlled study, 109 infertile patients aging 36-40 years old were selected to undergo the long protocol IVF. Eight weeks before starting the IVF cycle and during treatment, patients in Group 1 received 75 mg of DHEA once a day; patients in control group (Group 2) received placebo. The primary endpoint of the study was number of clinical pregnancy, live birth and miscarriage rates; secondary endpoint was modification of standard IVF parameters, including stimulation duration (days of rhFSH administration), E2 on HCG-day, endometrial thickness, number of retrieved oocytes, metaphase II oocytes, number of transferred embryos and score of leading embryos transferred.

resultsPatients in the DHEA group had a significantly higher live birth rate compared with controls (P<0.05). Conversely, miscarriage rate was higher for patients in the control group (P<0.05).

conclusionsDHEA supplementation may significantly improve IVF outcomes in infertile women with advanced reproductive age and normal ovarian reserve.

Indexed as

Fertilization in VitroAdultAge FactorsDehydroepiandrosteroneDouble-Blind MethodFemaleHumansOvarian ReservePregnancyPregnancy OutcomePregnancy RateTreatment OutcomeDehydroepiandrosterone

Identifiers

PMID25884390
PMCPMC4355976
OpenAlexW2118201643

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.