Evidence map›Paper›PMID 25884358›Full record

Trial reportBMC research notes2015

Recruiting older people at nutritional risk for clinical trials: what have we learned?

Cynthia Piantadosi, Ian M Chapman, Vasi Naganathan, Peter Hunter, Ian D Cameron, Renuka Visvanathan

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  11. Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults.International journal of environmental research and public health · 2018
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Cynthia PiantadosiDiscipline of Medicine, University of Adelaide, Adelaide, SA, 5000, Australia. cynthia.piantadosi@adelaide.edu.au.
Ian M ChapmanDiscipline of Medicine, University of Adelaide, Adelaide, SA, 5000, Australia. ian.chapman@adelaide.edu.au.
Vasi NaganathanCentre for Education and Research on Ageing, University of Sydney, Concord Hospital, Concord, NSW, 2139, Australia. vasi.naganathan@sydney.edu.au.
Peter HunterAlfred Health, Caulfield Hospital, 260, Caulfield, VIC, 3162, Australia. Peter.Hunter@cgmc.org.au.
Ian D CameronJohn Walsh Centre for Rehabilitation Research, Sydney Medical School, University of Sydney, Sydney, NSW, 2065, Australia. ian.cameron@sydney.edu.au.
Renuka VisvanathanDiscipline of Medicine, University of Adelaide, Adelaide, SA, 5000, Australia. renuka.visvanathan@adelaide.edu.au.
University of Adelaide · AUAlfred Health · AUConcord Repatriation General Hospital · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe difficulty of recruiting older people to clinical trials is well described, but there is limited information about effective ways to screen and recruit older people into trials, and the reasons for their reluctance to enrol. This paper examines recruitment efforts for a community-based health intervention study that targeted older adults.

methodsOne year randomized control trial. Undernourished men and women, aged ≥ 65 years and living independently in the community were recruited in three Australian states. Participants were allocated to either oral testosterone undecanoate and high calorie oral nutritional supplement or placebo medication and low calorie oral nutritional supplementation. Hospital admissions, functional status, nutritional health, muscle strength, and other variables were assessed.

results4023 potential participants were identified and 767 were screened by a variety of methods: hospital note screening, referrals from geriatric health services, advertising and media segments/appearances. 53 participants (7% of total screened) were recruited. The majority of potentially eligible participants declined participation in the trial after reading the information sheet. Media was the more successful method of recruiting, whereas contacting people identified by screening a large number of hospital records was not successful in recruiting any participants.

conclusionRecruitment of frail and older participants is difficult and multiple strategies are required to facilitate participation.

trial registrationAustralian Clinical Trial Registry: ACTRN 12610000356066 date registered 4/5/2010.

Indexed as

Dietary SupplementsPatient SelectionAgedAged, 80 and overAndrogensAustraliaDietFemaleFrail ElderlyHealth Services for the AgedHospitalizationHumansIndependent LivingMaleMalnutritionMuscle StrengthAndrogensTestosteronetestosterone undecanoate

Identifiers

PMID25884358
PMCPMC4415225
OpenAlexW2057678366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.