Trial reportBMC oral health2015
Enhancement of salivary human neutrophil peptide 1-3 levels by probiotic supplementation.
Trial report in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Unlocking the potential of probiotic administration in caries management: a systematic review.BMC oral health · 2024Pooled it
- Role of Probiotics in Oral Health Maintenance Among Patients Undergoing Fixed Orthodontic Therapy: a Systematic Review of Randomized Controlled Clinical Trials.Probiotics and antimicrobial proteins · 2020Pooled it
- Probiotics and oral health: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2017Pooled it
- The consumption of milk supplemented with probiotics decreases the occurrence of caries and the salivary concentration of hβD-3 in children.Clinical oral investigations · 2021Trial
- Significant elevation of salivary human neutrophil peptides 1-3 levels by probiotic milk in preschool children with severe early childhood caries: a randomized controlled trial.Clinical oral investigations · 2021Trial
- Reduction of Streptococcus mutans by probiotic milk: a multicenter randomized controlled trial.Clinical oral investigations · 2020Trial
- Modulation of Innate Immunity by Short-Chain Fatty Acids in Probiotic and Fecal Microbiota Transplantation Therapies for the Treatment of Colon Disorders.Probiotics and antimicrobial proteins · 2026Review
- The Variability of the Salivary Antimicrobial Peptide Profile: Impact of Lifestyle.International journal of molecular sciences · 2024Review
- Preventive effects of probiotics on dental caries in vitro and in vivo.BMC oral health · 2024Article
- A comprehensive review of the application of probiotics and postbiotics in oral health.Frontiers in cellular and infection microbiology · 2023Review
- From Mouth to Muscle: Exploring the Potential Relationship between the Oral Microbiome and Cancer-Related Cachexia.Microorganisms · 2022Review
- Role of Probiotics in Human Health.Cureus · 2022Review
- Effect of Microencapsulation Techniques on the Stress Resistance and Biological Activity of Bovine Lactoferricin-Lactoferrampin-EncodingFoods (Basel, Switzerland) · 2022Article
- Review
- Current status and future of delivery systems for prevention and treatment of infections in the oral cavity.Drug delivery and translational research · 2021Review
- A Review of the Role of Probiotic Supplementation in Dental Caries.Probiotics and antimicrobial proteins · 2020Review
- Increasing salivary IgA and reducingJournal of dental sciences · 2019Article
- Efficacy and Safety of Probiotics for Dental Caries in Preschool Children: A Systematic Review and Meta-analysis.Contemporary clinical dentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProbiotic supplementation can reduce mutans streptococci (MS) numbers. One of its proposed mechanisms is immunomodulation. Salivary human neutrophil peptide 1-3 (HNP1-3) levels have previously been demonstrated to be higher in caries-free than in caries-susceptible children, suggesting their preventive role against caries. We aimed to compare salivary HNP1-3 levels between an intervention group with probiotics and a control group.
methodsA randomized double-blinded clinical trial was conducted. Sixty schoolchildren were equally allocated to either an intervention or control group. The use of a probiotic strain, Lactobacillus paracasei SD1, has shown to reduce MS numbers in volunteers. In unstimulated whole saliva, HNP1-3 levels were assayed by ELISA, and MS and lactobacilli counts were assayed by colony counting at baseline (T0) and at 3 (T3), 6 (T6), and 12 months (T12). The International Caries Detection and Assessment system was used to assess caries status.
resultsIn the intervention group, salivary HNP1-3 levels were significantly greater than those in the control group at T3 and T6 (p < 0.001), whereas MS counts were significantly decreased (p < 0.01). In the intervention group, positive and negative correlations were found between HNP1-3 levels and lactobacilli counts and between MS and lactobacilli counts, respectively. However, there was no significant correlation between enhanced HNP1-3 levels and decreased MS numbers. The caries increment for the pit and fissure surface, but not for the smooth surfaces, was significantly decreased in the intervention group compared with the control group (p = 0.01).
conclusionsProbiotics can temporarily enhance salivary HNP1-3 levels; however, their action to reduce new pit and fissure caries probably involves microbial interactions.
trial registrationTCTR20130904001 (registration date: September 04, 2013).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.