Evidence map›Paper›PMID 25883934›Full record

ReviewFrontiers in cell and developmental biology2015

Physical exercise associated with NO production: signaling pathways and significance in health and disease.

Elena Y Dyakova, Leonid V Kapilevich, Victor G Shylko, Sergey V Popov, Yana Anfinogenova

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06932250 (Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06932250 narecruitingnot on this mapstarted 2025, after this paper: background citation

Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2030Enrolled118ConditionsHigh-risk PregnancyArmsLeg heating
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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  3. Metabolomic profiles of being physically active and less sedentary: a critical review.Metabolomics : Official journal of the Metabolomic Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elena Y DyakovaDepartment of Sporting Health Tourism, Physiology, and Medicine, National Research Tomsk State University Tomsk, Russia.
Leonid V KapilevichDepartment of Sporting Health Tourism, Physiology, and Medicine, National Research Tomsk State University Tomsk, Russia ; Institute of Physics and Technology, National Research Tomsk Polytechnic University Tomsk, Russia.
Victor G ShylkoDepartment of Sporting Health Tourism, Physiology, and Medicine, National Research Tomsk State University Tomsk, Russia.
Sergey V PopovFederal State Budgetary Scientific Institution "Research Institute for Cardiology," Tomsk, Russia.
Yana AnfinogenovaInstitute of Physics and Technology, National Research Tomsk Polytechnic University Tomsk, Russia ; Federal State Budgetary Scientific Institution "Research Institute for Cardiology," Tomsk, Russia.
National Research Tomsk State University · RUInstitute of Cardiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we review available data on nitric oxide (NO)-mediated signaling in skeletal muscle during physical exercise. Nitric oxide modulates skeletal myocyte function, hormone regulation, and local microcirculation. Nitric oxide underlies the therapeutic effects of physical activity whereas the pharmacological modulators of NO-mediated signaling are the promising therapeutic agents in different diseases. Nitric oxide production increases in skeletal muscle in response to physical activity. This molecule can alter energy supply in skeletal muscle through hormonal modulation. Mitochondria in skeletal muscle tissue are highly abundant and play a pivotal role in metabolism. Considering NO a plausible regulator of mitochondrial biogenesis that directly affects cellular respiration, we discuss the mechanisms of NO-induced mitochondrial biogenesis in the skeletal muscle cells. We also review available data on myokines, the molecules that are expressed and released by the muscle fibers and exert autocrine, paracrine and/or endocrine effects. The article suggests the presence of putative interplay between NO-mediated signaling and myokines in skeletal muscle. Data demonstrate an important role of NO in various diseases and suggest that physical training may improve health of patients with diabetes, chronic heart failure, and even degenerative muscle diseases. We conclude that NO-associated signaling represents a promising target for the treatment of various diseases and for the achievement of better athletic performance.

Indexed as

myokinenitric oxidephysical exersizephysiologyskeletal muscle

Identifiers

PMID25883934
PMCPMC4382985
OpenAlexW2062519870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.