ArticleEuropean journal of microbiology & immunology2015
Virulence genes in a probiotic E. coli product with a recorded long history of safe use.
Article in European journal of microbiology & immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Genomic Assessment, Metabolic Profile Mapping, and Anti-Helicobacter pylori Activity of Lactococcus lactis SK2-659 from Thai Fermented Green Mustard (Pak-kad-dong).Probiotics and antimicrobial proteins · 2026Article
- Isolation and Characterization of Lactic Acid Bacteria From "International journal of microbiology · 2025Article
- Functional genome analysis and anti-Helicobacter pylori activity of a novel bacteriocinogenic Lactococcus sp. NH2-7C from Thai fermented pork (Nham).Scientific reports · 2023Article
- Probiotic Characteristics and Safety Assessment ofJournal of microbiology and biotechnology · 2023Article
- Culture and genome-based analysis of four soil Clostridium isolates reveal their potential for antimicrobial production.BMC genomics · 2021Article
- GenomeFrontiers in genetics · 2021Article
- Article
- High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.Scientific reports · 2020Article
- Symbioflor2Microorganisms · 2020Article
- Assessment of Safety and Probiotic Traits ofFrontiers in microbiology · 2020Article
- Safety Evaluation and Colonisation Abilities of Four Lactic Acid Bacteria as Future Probiotics.Probiotics and antimicrobial proteins · 2019Article
- Effects of Live and Heat-InactivatedEuropean journal of microbiology & immunology · 2018Article
- Pilot Safety Evaluation of a Novel Strain ofFrontiers in genetics · 2018Article
- Evaluating the Safety of Potential ProbioticFrontiers in microbiology · 2018Article
- Therapeutic benefit of Salmonella attributed to LPS and TNF-α is exhaustible and dictated by tumor susceptibility.Oncotarget · 2017Article
- Insights from 100 Years of Research with ProbioticEuropean journal of microbiology & immunology · 2016Review
- Article
- A Review of Research Conducted with ProbioticInternational journal of bacteriology · 2016Review
- Campylobacter jejuni increases flagellar expression and adhesion of noninvasive Escherichia coli: effects on enterocytic Toll-like receptor 4 and CXCL-8 expression.Infection and immunity · 2015Article
- Pathotypes and probiotics: response to a commentary on the detection of a Shiga toxin producing Escherichia coli in a Crohn's disease patient.Gut pathogens · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The probiotic product Symbioflor2 (DSM 17252) is a bacterial concentrate of six different Escherichia coli genotypes, whose complete genome sequences are compared here, between each other as well as to other E. coli genomes. The genome sequences of Symbioflor2 E. coli components contained a number of virulence-associated genes. Their presence seems to be in conflict with a recorded history of safe use, and with the observed low frequency of adverse effects over a period of more than 6 years. The genome sequences were used to identify unique sequences for each component, for which strain-specific hybridization probes were designed. A colonization study was conducted whereby five volunteers were exposed to an exceptionally high single dose. The results showed that the probiotic E. coli could be detected for 3 months or longer in their stools, and this was in particular the case for those components containing higher numbers of virulence-associated genes. Adverse effects from this long-term colonization were absent. Thus, the presence of the identified virulence genes does not result in a pathogenic phenotype in the genetic background of these probiotic E. coli.
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Registered trials
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