Evidence map›Paper›PMID 25883789›Full record

ArticleCanadian journal of kidney health and disease2015

Oral salt and water versus intravenous saline for the prevention of acute kidney injury following contrast-enhanced computed tomography: study protocol for a pilot randomized trial.

Hiremath Swapnil, Greg A Knoll, Jeanne Françoise Kayibanda, Dean Fergusson, Benjamin Jw Chow, Wael Shabana, Erin Murphy, Tim Ramsay, Matthew James, Christine A White and 4 more

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02084771 (The Prevention of Acute Kidney Injury Following Contrast-Enhanced Computed Tomography), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02084771 phase4withdrawnnot on this map

The Prevention of Acute Kidney Injury Following Contrast-Enhanced Computed Tomography: A Pilot Trial of Oral Fluid Versus Intravenous Saline

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2014 to 2016Enrolled0ConditionsAcute Kidney InjuryArmsIntravenous Saline, Oral Salt and Water
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Hiremath SwapnilDivision of Nephrology, Faculty of Medicine, University of Ottawa, Ottawa, Canada ; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada ; Division of Nephrology, The Ottawa Hospital, Riverside Campus, 1967 Riverside Drive, Ottawa, Ontario K1H 7 W9 Canada.
Greg A KnollDivision of Nephrology, Faculty of Medicine, University of Ottawa, Ottawa, Canada ; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Jeanne Françoise KayibandaKidney Research Centre, Ottawa Health Research Institute, Ottawa, Canada.
Dean FergussonClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Benjamin Jw ChowDivision of Cardiology, University of Ottawa Heart Institute, Ottawa, Canada.
Wael ShabanaDepartment of Medical Imaging, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Erin MurphyOttawa Health Research Institute, Ottawa Hospital, Ottawa, Canada.
Tim RamsayFaculty of Medicine, Epidemiology& Community Medicine, University of Ottawa, Ottawa, Canada.
Matthew JamesDepartments of Medicine and Community Health Sciences, University of Calgary, Alberta, Canada.
Christine A WhiteDivision of Nephrology, Department of Medicine, Queen's University, Kingston, Canada.
Amit GargDivision of Nephrology, Department of Medicine, University of Western Ontario, London, Canada.
Ron WaldDivision of Nephrology, Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, Canada.
Jeffrey HochInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Ayub AkbariDivision of Nephrology, Faculty of Medicine, University of Ottawa, Ottawa, Canada ; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Ottawa Hospital · CAUniversity of Ottawa · CAOttawa Hospital Research InstituteUniversity of Toronto · CAQueen's University · CAUniversity of Calgary · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough intravenous saline is the accepted prophylactic measure for the prevention of contrast- induced acute kidney injury, the oral route could offer an equivalent, practical, and cost saving approach. A systematic review of randomized trials that compared oral versus intravenous volume expansion for the prevention of radiocontrast-induced nephropathy in patients receiving arterial contrast reported no significant difference in the risk of contrast induced acute kidney injury between the oral and intravenous arms. Most trials for contrast nephropathy prevention have been in the setting of arterial contrast such as with cardiac catheterization, and not with venous contrast, such as computed tomography. The aim of this paper is to describe the protocol of a pilot trial comparing the effect of oral salt and water versus intravenous saline on the prevention of Acute Kidney Injury following contrast-enhanced computed tomography.

methodsOur study is a pilot, single-centre parallel randomized controlled trial. To be included, participants must be at stage 4 of chronic kidney disease as defined by a glomerular filtration rate <30 mL/min/1.73 m(2), aged greater than 18 years and to undergo an outpatient contrast-enhanced computer tomography of the chest or abdomen. A total 50 patients will be randomised to receive either oral salt and water or intravenous isotonic saline. The primary outcome is feasibility, including estimates of recruitment rate, adherence to intervention and completeness of follow-up to assist in planning the definitive trial. The secondary outcome is safety and includes adverse events with oral salt and water loading as compared to intravenous isotonic saline. DISCUSSION: The results of this pilot trial will provide critical information to plan a definitive trial to test the efficacy of the route of volume loading regimens in prevention of acute kidney injury after contrast-enhanced CT scans.

trial registrationThe trial is registered at the US National Institutes of Health (ClinicalTrials.gov) # NCT02084771.

Indexed as

Contrast-induced nephropathyIntravenous salineOral Salt and WaterRandomized controlled trial

Identifiers

PMID25883789
PMCPMC4399084
OpenAlexW2108613773

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.