Evidence map›Paper›PMID 25883674›Full record

ArticleNano today2014

Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom.

Weiqiang Chen, Yue Shao, Xiang Li, Gang Zhao, Jianping Fu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano today, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 213 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Stem cells in organogenesis and regeneration.Stem cell research & therapy · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Plant Cellulose as a Substrate for 3D Neural Stem Cell Culture.Bioengineering (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Review
  17. Review
  18. Microfluidic Systems for Neural Cell Studies.Bioengineering (Basel, Switzerland) · 2023
    Review
  19. Review
  20. Biomimetic Convex Implant for Corneal Regeneration Through 3D Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Weiqiang ChenIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Yue ShaoIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Xiang LiIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Gang ZhaoDepartment of Electronic Science and Technology, University of Science and Technology of China, Hefei 230027, P. R. China.
Jianping FuIntegrated Biosystems and Biomechanics Laboratory, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · USUniversity of Science and Technology of China · CN

Funding

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1): (BPCA)UL1RR024986 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHANLEY, THOMAS P. · 2007 to 2011
$51.2M
VACCINIA PSA FOR ANDROGEN-MODULATED POST-SURGICAL RECURRENCE OF PROSTATE CANCERP50CA069568 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COONEY, KATHLEEN A · 1995 to 2013
$31.3M
2012-Directed Differentiation of Stem Cells to Cardiomyocytes Using Optically ActR21HL114011 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HART, ANASTASIOS JOHN · 2013 to 2014
$429k
Ultrasound-mediated Directed Osteogenic Differentiation of Mesenchymal Stem CellsR21EB017078 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DENG, CHERI X, FU, JIANPING · 2014 to 2015
$428k
NCI NIH HHS P50 CA069568NCRR NIH HHS UL1 RR024986NHLBI NIH HHS R21 HL114011NIBIB NIH HHS R21 EB017078
6 · The paper itself

Abstract

During embryogenesis and tissue maintenance and repair in an adult organism, a myriad of stem cells are regulated by their surrounding extracellular matrix (ECM) enriched with tissue/organ-specific nanoscale topographical cues to adopt different fates and functions. Attributed to their capability of self-renewal and differentiation into most types of somatic cells, stem cells also hold tremendous promise for regenerative medicine and drug screening. However, a major challenge remains as to achieve fate control of stem cells

Indexed as

BiomaterialsMechanobiologyNanotopographyStem cellTissue engineering and regenerative medicine

Identifiers

PMID25883674
PMCPMC4394389
OpenAlexW2091607038

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.