Evidence map›Paper›PMID 25883627›Full record

ArticleNeural regeneration research2015

Ethanol extract of Oenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus.

Bai Hui Chen, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Bich Na Shin, Ji Hyeon Ahn, Seok Joon Hwang, Bing Chun Yan, Hyun Jin Tae, Jae Chul Lee and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Antioxidants (Basel, Switzerland) · 2022
    Article
  3. Article
  4. A Review ofEvidence-based complementary and alternative medicine : eCAM · 2019
    Review
  5. Chinese medical journal · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Bai Hui ChenDepartment of Physiology, College of Medicine, and Institute of Neurodegeneration and Neuroregeneration, Hallym University, Chuncheon, South Korea.
Joon Ha ParkDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Jeong Hwi ChoDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
In Hye KimDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Bich Na ShinDepartment of Physiology, College of Medicine, and Institute of Neurodegeneration and Neuroregeneration, Hallym University, Chuncheon, South Korea.
Ji Hyeon AhnDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Seok Joon HwangDepartment of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, South Korea.
Bing Chun YanDepartment of Integrative Traditional & Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China.
Hyun Jin TaeDepartment of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon, South Korea.
Jae Chul LeeDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Eun Joo BaeDepartment of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chunchen, South Korea.
Yun Lyul LeeDepartment of Physiology, College of Medicine, and Institute of Neurodegeneration and Neuroregeneration, Hallym University, Chuncheon, South Korea.
Jong Dai KimDepartment of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, South Korea.
Moo-Ho WonDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea.
Il Jun KangDepartment of Food Science and Nutrition, Hallym University, Chuncheon, South Korea.
Kangwon National University · KRHallym University · KRHallym University Chuncheon Sacred Heart Hospital · KRYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oenanthe javanica is an aquatic perennial herb that belongs to the Oenanthe genus in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glutamate-induced neurotoxicity. However, few studies regarding effects of Oenanthe javanica on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract of Oenanthe javanica on cell proliferation and neuroblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67 (an endogenous marker for cell proliferation) and doublecortin (a marker for neuroblast). Our results showed that Oenanthe javanica extract significantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was significantly increased in the dentate gyrus of the Oenanthe javanica extract-treated group compared with the control group. However, we did not find that vascular endothelial growth factor expression was increased in the Oenanthe javanica extract-treated group compared with the control group. These results indicate that Oenanthe javanica extract improves cell proliferation and neuroblast differentiation by increasing brain-derived neurotrophic factor immunoreactivity in the rat dentate gyrus.

Indexed as

brain-derived neurotrophic factorcell proliferationnerve regenerationneural regenerationneuroblast differentiationOenanthe javanica extractratvascular endothelial growth factor

Identifiers

PMID25883627
PMCPMC4392676
OpenAlexW2070590305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.