Evidence map›Paper›PMID 25883586›Full record

ReviewFrontiers in neurology2015

Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies.

Bridgette D Semple, Sangmi Lee, Raha Sadjadi, Nora Fritz, Jaclyn Carlson, Carrie Griep, Vanessa Ho, Patrice Jang, Annick Lamb, Beth Popolizio and 6 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Sex matters: repetitive mild traumatic brain injury in adolescent rats.Annals of clinical and translational neurology · 2017
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Bridgette D SempleDepartment of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA ; Department of Medicine, Royal Melbourne Hospital, University of Melbourne , Parkville, VIC , Australia.
Sangmi LeeDepartment of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA.
Raha SadjadiDepartment of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA.
Nora FritzKennedy Krieger Institute, John Hopkins University , Baltimore, MD , USA.
Jaclyn CarlsonDepartment of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA.
Carrie GriepSan Francisco State University Graduate Program in Physical Therapy, University of California San Francisco , San Francisco, CA , USA.
Vanessa HoSan Francisco State University Graduate Program in Physical Therapy, University of California San Francisco , San Francisco, CA , USA.
Patrice JangSan Francisco State University Graduate Program in Physical Therapy, University of California San Francisco , San Francisco, CA , USA.
Annick LambSan Francisco State University Graduate Program in Physical Therapy, University of California San Francisco , San Francisco, CA , USA.
Beth PopolizioSan Francisco State University Graduate Program in Physical Therapy, University of California San Francisco , San Francisco, CA , USA.
Sonia SainiSan Francisco State University Graduate Program in Physical Therapy, University of California San Francisco , San Francisco, CA , USA.
Jeffrey J BazarianSchool of Medicine and Dentistry, University of Rochester Medical Center , Rochester, NY , USA.
Mayumi L PrinsDepartment of Neurosurgery, University of California Los Angeles David Geffen School of Medicine , Los Angeles, CA , USA.
Donna M FerrieroDepartment of Pediatrics, University of California San Francisco , San Francisco, CA , USA ; Department of Neurology, University of California San Francisco , San Francisco, CA , USA.
D Michele BassoSchool of Health and Rehabilitation Sciences, Ohio State University , Columbus, OH , USA.
Linda J Noble-HaeussleinDepartment of Neurological Surgery, University of California San Francisco , San Francisco, CA , USA ; Department of Physical Therapy and Rehabilitation Sciences, University of California San Francisco , San Francisco, CA , USA.
San Francisco State University · USNeurological Surgery · USKennedy Krieger Institute · USThe Ohio State University · USThe Royal Melbourne Hospital · AUUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Rochester Medical Center · US

Funding

Behavioral and Cellular Determinants of Treadmill Training and Recovery After SCIR01NS074882 · NINDS · OHIO STATE UNIVERSITY · PI BASSO, D M · 2011 to 2020
$3.3M
Trauma to Developing Brain-Injury and Repair MechanismsR01NS050159 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOBLE, LINDA J. · 2005 to 2013
$2.8M
Determinants of vulnerability and recovery after trauma to the developing brainR01NS077767 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOBLE, LINDA J. · 2012 to 2016
$1.7M
NINDS NIH HHS R01 NS050159NINDS NIH HHS R01 NS074882NINDS NIH HHS R01 NS077767
6 · The paper itself

Abstract

Sports-related concussions are particularly common during adolescence, a time when even mild brain injuries may disrupt ongoing brain maturation and result in long-term complications. A recent focus on the consequences of repetitive concussions among professional athletes has prompted the development of several new experimental models in rodents, as well as the revision of guidelines for best management of sports concussions. Here, we consider the utility of rodent models to understand the functional consequences and pathobiology of concussions in the developing brain, identifying the unique behavioral and pathological signatures of concussive brain injuries. The impact of repetitive concussions on behavioral consequences and injury progression is also addressed. In particular, we focus on the epidemiological, clinical, and experimental evidence underlying current recommendations for physical and cognitive rest after concussion, and highlight key areas in which further research is needed. Lastly, we consider how best to promote recovery after injury, recognizing that optimally timed, activity-based rehabilitative strategies may hold promise for the adolescent athlete who has sustained single or repetitive concussions. The purpose of this review is to inform the clinical research community as it strives to develop and optimize evidence-based guidelines for the concussed adolescent, in terms of both acute and long-term management.

Indexed as

adolescentathletesbehaviorconcussionexerciseexperimental modelspathologyrehabilitation

Identifiers

PMID25883586
PMCPMC4382966
OpenAlexW1986978286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.