ReviewFrontiers in physiology2015
Individualized medicine and the microbiome in reproductive tract.
Review in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Unveiling the placental bacterial microbiota: implications for maternal and infant health.Frontiers in physiology · 2025Review
- Endometrial Cancer: A Pilot Study of the Tissue Microbiota.Microorganisms · 2024Article
- Six months of different exercise type in sedentary primary schoolchildren: impact on physical fitness and saliva microbiota composition.Frontiers in nutrition · 2024Article
- Inferring microbial interactions with their environment from genomic and metagenomic data.PLoS computational biology · 2023Article
- Comparison of Gut Microbiome in Neonates Born by Caesarean Section and Vaginal Seeding with Gut Microbiomes of Neonates Born by Caesarean Section Without Vaginal Seeding and Neonates Born by Vaginal Delivery.Materia socio-medica · 2023Article
- Vaginal and Cervical Microbiota Composition in Patients with Endometrial Cancer.International journal of molecular sciences · 2023Article
- Female reproductive tract microbiome and early miscarriages.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2023Review
- Minimizing the number of optimizations for efficient community dynamic flux balance analysis.PLoS computational biology · 2020Article
- Metabolite-mediated modelling of microbial community dynamics captures emergent behaviour more effectively than species-species modelling.Journal of the Royal Society, Interface · 2019Article
- Modifications in Vaginal Microbiota and Their Influence on Drug Release: Challenges and Opportunities.Pharmaceutics · 2019Review
- The genital tract and rectal microbiomes: their role in HIV susceptibility and prevention in women.Journal of the International AIDS Society · 2019Review
- The Transformative Possibilities of the Microbiota and Mycobiota for Health, Disease, Aging, and Technological Innovation.Biomedicines · 2019Article
- Dynamics of Vaginal and Rectal Microbiota Over Several Menstrual Cycles in Female Cynomolgus Macaques.Frontiers in cellular and infection microbiology · 2019Article
- Article
- Associations of the Oral Microbiota with Obesity and Menarche in Inner City Girls.Journal of childhood obesity · 2019Article
- Male Partners of Infertile Couples With Seminal Positivity for Markers of Bacterial Vaginosis Have Impaired Fertility.American journal of men's health · 2018Article
- Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141,460 Individuals.Journal of clinical medicine · 2018Article
- Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer.Archives of gynecology and obstetrics · 2018Review
- The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.Cancer research · 2017Review
- Potential contribution of the uterine microbiome in the development of endometrial cancer.Genome medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (10(14)) outnumber human cells by 10 to 1 and account for 3 × 10(6) genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our "other genome" and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (HMP) and the MetaHIT Project have helped catalog these microbial genomes using culture-independent, high-throughput, next-generation sequencing. This manuscript will describe recent efforts to define microbial diversity in the female reproductive tract because of the impact that microbial function has on reproductive efficiency. In this review, we will discuss current evidence that microbial communities are critical for maintaining reproductive health and how perturbations of microbial community structures can impact reproductive health from the aspect of infection, reproductive cyclicity, pregnancy, and disease states. Investigations of the human microbiome are propelling interventional strategies from treating medical populations to treating individual patients. In particular, we highlight how understanding and defining microbial community structures in different disease and physiological states have lead to the discovery of biomarkers and, more importantly, the development and implementation of microbial intervention strategies (probiotics) into modern day medicine. Finally this review will conclude with a literature summary of the effectiveness of microbial intervention strategies that have been implemented in animal and human models of disease and the potential for integrating these microbial intervention strategies into standard clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.