Evidence map›Paper›PMID 25883536›Full record

ArticleThrombosis journal2015

Thrombosis in vasculitis: from pathogenesis to treatment.

Giacomo Emmi, Elena Silvestri, Danilo Squatrito, Amedeo Amedei, Elena Niccolai, Mario Milco D'Elios, Chiara Della Bella, Alessia Grassi, Matteo Becatti, Claudia Fiorillo and 3 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Thrombosis journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06807788 (Evaluation of Platelet Aggregability in Patients with Takayasu's Arteritis), which is not on this map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06807788 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of Platelet Aggregability in Patients with Takayasu's Arteritis

TypeobservationalSponsorJose Carlos NicolauRan2024 to 2027Enrolled100ConditionsTakayasu Arteritis (TAK), Vasculitis, SystemicArmsClopidogrel
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.

  1. Pooled it
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  5. Concurrent Chronic Limb Threatening Ischemia and Deep Vein Thrombosis of a Limb in Patient with Systemic Lupus Erythematosus: A Case Report.The International journal of angiology : official publication of the International College of Angiology, Inc · 2026
    Article
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  10. Can mycophenolate mofetil be an effective option in the treatment of vascular Behçet's Syndrome.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Giacomo Emmi *Department of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Elena Silvestri *Department of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Danilo SquatritoDepartment of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Elena NiccolaiDepartment of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Mario Milco D'EliosDepartment of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Chiara Della BellaDepartment of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Alessia GrassiDepartment of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
Matteo BecattiDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Claudia FiorilloDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Lorenzo EmmiSOD Interdisciplinary Internal Medicine, Center for Autoimmune Systemic Diseases-Behçet Center and Lupus Clinic-AOU Careggi Hospital of Florence, Florence, Italy.
Augusto VaglioNephrology Unit, University Hospital of Parma, Parma, Italy.
Domenico PriscoDepartment of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla, 3, 50134 Florence, Italy.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected. Inflammation-induced thrombosis is by now considered a feature not only of autoimmune rheumatic diseases, but also of systemic vasculitides such as Behçet's syndrome, ANCA-associated vasculitis or giant cells arteritis, especially during active disease. These findings have important consequences in terms of management and treatment. Indeed, Behçet'syndrome requires immunosuppressive agents for vascular involvement rather than anticoagulation or antiplatelet therapy, and it is conceivable that also in ANCA-associated vasculitis or large vessel-vasculitis an aggressive anti-inflammatory treatment during active disease could reduce the risk of thrombotic events in early stages. In this review we discuss thrombosis in vasculitides, especially in Behçet's syndrome, ANCA-associated vasculitis and large-vessel vasculitis, and provide pathogenetic and clinical clues for the different specialists involved in the care of these patients.

Indexed as

ANCA associated vasculitisBehçet syndromeDeep vein thrombosisInflammation-induced thrombosisLarge vessel vasculitisThrombo-embolic disease

Identifiers

PMID25883536
PMCPMC4399148
OpenAlexW2125412499

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.