Evidence map›Paper›PMID 25883419›Full record

ArticleIndian journal of clinical biochemistry : IJCB2015

Genetic polymorphisms associated with breast cancer in malaysian cohort.

Jagdish Kaur Chahil, Khamsigan Munretnam, Nurulhafizah Samsudin, Say Hean Lye, Nikman Adli Nor Hashim, Nurul Hanis Ramzi, Sharmila Velapasamy, Ler Lian Wee, Livy Alex

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Evaluation ofMedicina (Kaunas, Lithuania) · 2023
    Pooled it
  2. Association between four MMP-9 polymorphisms and breast cancer risk: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  3. Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population.Asian Pacific journal of cancer prevention : APJCP · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jagdish Kaur ChahilMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Khamsigan MunretnamMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Nurulhafizah SamsudinMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Say Hean LyeMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Nikman Adli Nor HashimMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Nurul Hanis RamziMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Sharmila VelapasamyMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Ler Lian WeeMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
Livy AlexMolecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies have discovered multiple single nucleotide polymorphisms (SNPs) associated with the risk of common diseases. The objective of this study was to demonstrate the replication of previously published SNPs that showed statistical significance for breast cancer in the Malaysian population. In this case-control study, 80 subjects for each group were recruited from various hospitals in Malaysia. A total of 768 SNPs were genotyped and analyzed to distinguish risk and protective alleles. A total of three SNPs were found to be associated with increased risk of breast cancer while six SNPs showed protective effect. All nine were statistically significant SNPs (p ≤ 0.01), five SNPs from previous studies were successfully replicated in our study. Significant modifiable (diet) and non-modifiable (family history of breast cancer in first degree relative) risk factors were also observed. We identified nine SNPs from this study to be either conferring susceptibility or protection to breast cancer which may serve as potential markers in risk prediction.

Indexed as

AssociationBreast cancerCase–control studyRisk prediction modelSNP

Identifiers

PMID25883419
PMCPMC4393382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.