Evidence map›Paper›PMID 25883092›Full record

ArticleCancer research2015

Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites.

Qilong Wang, Yi Ren, Jingyao Mu, Nejat K Egilmez, Xiaoyin Zhuang, Zhongbin Deng, Lifeng Zhang, Jun Yan, Donald Miller, Huang-Ge Zhang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 198 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 3 syntheses or guidelines pooled it, 333 citations in OpenAlex.

  1. Pooled it
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  6. Citrus limon-Derived Extracellular Vesicles Promote Hair Growth.Applied biochemistry and biotechnology · 2026
    Article
  7. Green nanomedicine for cancer therapy.Chinese medical journal · 2026
    Review
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138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Qilong WangLouisville Veterans Administration Medical Center, Louisville, Kentucky. James Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky.
Yi RenDepartment of Breast and Thyroid Surgery, Huai'an First People's Hospital, Huai'an, Jiangsu, China.
Jingyao MuJames Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky.
Nejat K EgilmezJames Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky.
Xiaoyin ZhuangJames Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, Kentucky.
Zhongbin DengJames Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, Kentucky.
Lifeng ZhangJames Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, Kentucky.
Jun YanJames Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, Kentucky.
Donald MillerJames Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, Kentucky.
Huang-Ge ZhangLouisville Veterans Administration Medical Center, Louisville, Kentucky. James Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky. H0Zhan17@louisville.edu.
University of Louisville · USUnited States Department of Veterans Affairs · USHuaian First People’s Hospital · CN

Funding

Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiationR01AT004294 · NCCIH · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2007 to 2010
$1.4M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH2TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI GUO, PEIXUAN, ZHANG, HUANG-GE · 2013 to 2014
$867k
Exosomal TRAF2-CSN5 complex mediated inflammation promotes tumor growthI01BX000962 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI ZHANG, HUANG-GE · 2011 to 2014
–
BLRD VA I01 BX000962NCATS NIH HHS UH2 TR000875NCATS NIH HHS UH2TR000875NCCIH NIH HHS R01 AT004294
6 · The paper itself

Abstract

Inflammation is a hallmark of cancer. Activated immune cells are intrinsically capable of homing to inflammatory sites. Using three inflammatory-driven disease mouse models, we show that grapefruit-derived nanovectors (GNV) coated with inflammatory-related receptor enriched membranes of activated leukocytes (IGNVs) are enhanced for homing to inflammatory tumor tissues. Blocking LFA-1 or CXCR1 and CXCR2 on the IGNVs significantly inhibits IGNV homing to the inflammatory tissue. The therapeutic potential of IGNVs was further demonstrated by enhancing the chemotherapeutic effect as shown by inhibition of tumor growth in two tumor models and inhibiting the inflammatory effects of dextran sulfate sodium-induced mouse colitis. The fact that IGNVs are capable of homing to inflammatory tissue and that chemokines are overexpressed in diseased human tissue provides the rationale for using IGNVs to more directly deliver therapeutic agents to inflammatory tumor sites and the rationale for the use of IGNVs as treatment for certain cancers in personalized medicine.

Indexed as

Adoptive TransferAnimalsCitrus paradisiColonic NeoplasmsDisease Models, AnimalFemaleHumansHuman Umbilical Vein Endothelial CellsInflammationLeukocytesLymphoma, T-CellMammary Neoplasms, ExperimentalMiceNanoparticlesNeoplasmsT-Lymphocytes

Identifiers

PMID25883092
PMCPMC4470740
OpenAlexW1993337563

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.