Evidence map›Paper›PMID 25882753›Full record

ArticleNeuroImage2016

The PLORAS Database: A data repository for Predicting Language Outcome and Recovery After Stroke.

Mohamed L Seghier, Elnas Patel, Susan Prejawa, Sue Ramsden, Andre Selmer, Louise Lim, Rachel Browne, Johanna Rae, Zula Haigh, Deborah Ezekiel and 3 more

Abstract read
In one paragraph

Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Trial
  2. Lesion-site-dependent responses to therapy after aphasic stroke.Journal of neurology, neurosurgery, and psychiatry · 2018
    Trial
  3. Trial
  4. Article
  5. Article
  6. Article
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  8. Precision-Optimised Post-Stroke Prognoses.Annals of clinical and translational neurology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
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  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohamed L SeghierWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Elnas PatelWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Susan PrejawaWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Sue RamsdenWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Andre SelmerWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Louise LimWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Rachel BrowneWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Johanna RaeWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Zula HaighWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Deborah EzekielWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Thomas M H HopeWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Alex P LeffWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
Cathy J PriceWellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK. Electronic address: c.j.price@ucl.ac.uk.

Funding

Medical Research Council MR/M023672/1Wellcome Trust 091593Wellcome Trust 097720
6 · The paper itself

Abstract

The PLORAS Database is a relational repository of anatomical and functional imaging data that has primarily been acquired from stroke survivors, along with standardized scores on a wide range of sensory, motor and cognitive abilities, demographic details and medical history. As of January 2015, we have data from 750 patients with an expected accrual rate of 200 patients per year. Expansion will accelerate as we extend our collaborations. The main aim of the database is to Predict Language Outcome and Recovery After Stroke (PLORAS) on the basis of a single structural (anatomical) brain scan that indexes the stereotactic location and extent of brain damage. Predictions are made for individual patients by indicating how other patients with the most similar brain damage, cognitive abilities and demographic details recovered their language skills over time. Predictions are validated by longitudinal follow-ups of patients who initially presented with speech and language difficulties. The PLORAS Database can also be used to predict recovery of other cognitive abilities on the basis of anatomical brain scans. The functional imaging data can be used to understand the neural mechanisms that support recovery from brain damage; and all the data can be used to understand the main sources of inter-subject variability in structure-function mappings in the human brain. Data will be made available for sharing, subject to: funding, ethical approval and patient consent.

Indexed as

Databases, FactualStroke RehabilitationTreatment OutcomeBrainCognitionHumansImage Processing, Computer-AssistedLanguage DisordersMagnetic Resonance ImagingPrognosisQuality ControlRecovery of FunctionSpeech DisordersStroke

Identifiers

PMID25882753
PMCPMC4658335

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.