Evidence map›Paper›PMID 25882604›Full record

Trial reportBiological research for nursing2015

Moderating Effects of Genetic Polymorphisms on Improvements in Cognitive Impairment in Breast Cancer Survivors Participating in a 6-Week Mindfulness-Based Stress Reduction Program.

Cecile A Lengacher, Richard R Reich, Kevin E Kip, Carly L Paterson, Hyun Y Park, Sophia Ramesar, Heather S L Jim, Carissa B Alinat, Jong Y Park

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biological research for nursing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Mindfulness-based stress reduction for women diagnosed with breast cancer.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Elevated Oxidative Stress and DNA Damage in Cortical Neurons of Chemotherapy Patients.Journal of neuropathology and experimental neurology · 2021
    Article
  9. Cognitive Effects of Cancer and Cancer Treatments.Annual review of clinical psychology · 2018
    Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cecile A LengacherCollege of Nursing, University of South Florida, Tampa, FL, USA Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA clengach@health.usf.edu.
Richard R ReichCollege of Arts and Sciences, University of South Florida Sarasota-Manatee, Sarasota, FL, USA Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
Kevin E KipCollege of Nursing, University of South Florida, Tampa, FL, USA.
Carly L PatersonCollege of Nursing, University of South Florida, Tampa, FL, USA.
Hyun Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Sophia RamesarCollege of Nursing, University of South Florida, Tampa, FL, USA.
Heather S L JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.
Carissa B AlinatCollege of Nursing, University of South Florida, Tampa, FL, USA.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.

Funding

MBSR Symptom Cluster Trial for Breast Cancer SurvivorsR01CA131080 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2009 to 2013
$2.7M
NCI NIH HHS 1R01CA131080-01A2NCI NIH HHS R01 CA131080
6 · The paper itself

Abstract

Breast cancer (BC) survivors often report cognitive impairment, which may be influenced by single-nucleotide polymorphisms (SNPs). The purpose of this study was to test whether particular SNPs were associated with changes in cognitive function in BC survivors and whether these polymorphisms moderated cognitive improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. BC survivors recruited from Moffitt Cancer Center and the University of South Florida's Breast Health Program, who had completed adjuvant radiation and/or chemotherapy treatment, were randomized to either the 6-week MBSR(BC) program (n = 37) or usual care (UC; n = 35) group. Measures of cognitive function and demographic and clinical history data were attained at baseline and at 6 and 12 weeks. A total of 10 SNPs from eight genes known to be related to cognitive function were analyzed using blood samples. Results showed that SNPs in four genes (ankyrin repeat and kinase domain containing 1 [ANKK1], apolipoprotein E [APOE], methylenetetrahydrofolate reductase [MTHFR], and solute carrier family 6 member 4 [SLC6A4]) were associated with cognitive impairment. Further, rs1800497 in ANKK1 was significantly associated with improvements in cognitive impairment in response to MBSR(BC). These results may help to identify individuals who would be better served by MBSR(BC) or other interventions.

Indexed as

MindfulnessAdultAgedBreast NeoplasmsCognitive DysfunctionFemaleHumansMiddle AgedPolymorphism, GeneticStress, PsychologicalSurvivorsTreatment Outcomebreast cancercognitive functiongenetic polymorphismgeneticsMBSR(BC)mindfulness-based stress reduction

Identifiers

PMID25882604
PMCPMC10131135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.