ArticleThe Journal of investigative dermatology2015
How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Near missed diagnosis of Merkel cell carcinoma in a young immunocompetent woman with a recurrent left-arm mass: A case report.Clinical case reports · 2023Article
- Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility.The Biochemical journal · 2020Article
- Merkel Cell Polyomavirus and Merkel Cell Carcinoma.Cancers · 2020Review
- The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions.Frontiers in microbiology · 2018Article
- Talimogene laherparepvec for regionally advanced Merkel cell carcinoma: A report of 2 cases.JAAD case reports · 2017Article
- Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study.Cancer · 2017Article
- Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection.The Journal of investigative dermatology · 2017Article
- Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas.Immunotherapy · 2016Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Merkel cell polyomavirus (MCPyV), discovered in 2008, drives the development of most Merkel cell carcinomas (MCCs) through several canonical mechanisms. A glaring gap in our knowledge remains the basis by which MCPyV, among all 12 human polyomaviruses, is the only one that causes cancer in humans. Moreover, initial attempts by numerous groups have failed to reproduce MCC in mice using oncoproteins from this polyomavirus. Verhaegen et al. report MCPyV small T-antigen-expressing transgenic mice that now provide insight into in vivo transformation mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.