ArticleCerebral cortex (New York, N.Y. : 1991)2016
Context Memory Decline in Middle Aged Adults is Related to Changes in Prefrontal Cortex Function.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Demands on perceptual and mnemonic fidelity are a key determinant of age-related cognitive decline throughout the lifespan.Journal of experimental psychology. General · 2024Article
- Menopause Status and Within-Group Differences in Chronological Age Affect the Functional Neural Correlates of Spatial Context Memory in Middle-Aged Females.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Curcumin improves reversal learning in middle-aged rhesus monkeys.Behavioral neuroscience · 2022Article
- Mitochondrial aconitase 1 regulates age-related memory impairment via autophagy/mitophagy-mediated neural plasticity in middle-aged flies.Aging cell · 2021Article
- Healthy Middle-Aged Adults Have Preserved Mnemonic Discrimination and Integration, While Showing No Detectable Memory Benefits.Frontiers in psychology · 2021Article
- Sex differences in brain aging among adults with family history of Alzheimer's disease and APOE4 genetic risk.NeuroImage. Clinical · 2021Article
- The Effects of a Novel Non-catechol Dopamine Partial Agonist on Working Memory in the Aged Rhesus Monkey.Frontiers in aging neuroscience · 2021Article
- Impaired memory-guided attention in asymptomatic APOE4 carriers.Scientific reports · 2019Article
- The Middle-Aged Brain: Biological sex and sex hormones shape memory circuitry.Current opinion in behavioral sciences · 2018Article
- Acute effect of Ethanol and Taurine on frontal cortex absolute beta power before and after exercise.PloS one · 2018Article
- Dynamic range in BOLD modulation: lifespan aging trajectories and association with performance.Neurobiology of aging · 2017Article
- Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys.GeroScience · 2017Article
- Reorganization of Functional Networks in Verbal Working Memory Circuitry in Early Midlife: The Impact of Sex and Menopausal Status.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Age-related reduction of BOLD modulation to cognitive difficulty predicts poorer task accuracy and poorer fluid reasoning ability.NeuroImage · 2017Article
- Family history and APOE4 risk for Alzheimer's disease impact the neural correlates of episodic memory by early midlife.NeuroImage. Clinical · 2017Article
- Modes of Effective Connectivity within Cortical Pathways Are Distinguished for Different Categories of Visual Context: An fMRI Study.Frontiers in behavioral neuroscience · 2017Article
- Impact of Sex and Menopausal Status on Episodic Memory Circuitry in Early Midlife.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The neural correlates of recollection and retrieval monitoring: Relationships with age and recollection performance.NeuroImage · 2016Article
- Frequency-specific insight into short-term memory capacity.Journal of neurophysiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to encode and retrieve spatial and temporal contextual details of episodic memories (context memory) begins to decline at midlife. In the current study, event-related fMRI was used to investigate the neural correlates of context memory decline in healthy middle aged adults (MA) compared with young adults (YA). Participants were scanned while performing easy and hard versions of spatial and temporal context memory tasks. Scans were obtained at encoding and retrieval. Significant reductions in context memory retrieval accuracy were observed in MA, compared with YA. The fMRI results revealed that overall, both groups exhibited similar patterns of brain activity in parahippocampal cortex, ventral occipito-temporal regions and prefrontal cortex (PFC) during encoding. In contrast, at retrieval, there were group differences in ventral occipito-temporal and PFC activity, due to these regions being more activated in MA, compared with YA. Furthermore, only in YA, increased encoding activity in ventrolateral PFC, and increased retrieval activity in occipital cortex, predicted increased retrieval accuracy. In MA, increased retrieval activity in anterior PFC predicted increased retrieval accuracy. These results suggest that there are changes in PFC contributions to context memory at midlife.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.