ArticleMedicine2015
Diagnostic accuracy of contrast-enhanced computed tomography and positron emission tomography with 18-FDG in identifying malignant solitary pulmonary nodules.
Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The value of 18F-FDG-PET/CT in the diagnosis of solitary pulmonary nodules: A meta-analysis.Medicine · 2018Pooled it
- Contrast-enhanced computed tomography versus positron emission tomography/positron emission tomography-computed tomography in suspected lung cancer: a systematic review and meta-analysis of diagnostic accuracy studies.Therapeutic advances in respiratory diseasePooled it
- Image analysis:Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography SUVMax in deciding on a computed tomography-guided lung biopsy in solid solitary pulmonary nodules.Revista da Associacao Medica Brasileira (1992) · 2025Article
- FDG avid solitary pulmonary nodule mimicking lung cancer.Radiology case reports · 2022Article
- Contrast-enhanced computed tomography prior to percutaneous transthoracic needle biopsy reduces the incidence of hemorrhage.Annals of translational medicine · 2021Article
- A retrospective study analyzing missed diagnosis of lung metastases at their early stages on computed tomography.Journal of thoracic disease · 2019Article
- Comparing the diagnostic value ofJournal of thoracic disease · 2019Article
- The value of 18F-FDG PET/CT in the diagnosis of different size of solitary pulmonary nodules.Medicine · 2019Article
- Performance of FDG-PET/CT in solitary pulmonary nodule based on pre-test likelihood of malignancy: results from the ITALIAN retrospective multicenter trial.European journal of nuclear medicine and molecular imaging · 2018Article
- Ability of FDG PET and CT radiomics features to differentiate between primary and metastatic lung lesions.European journal of nuclear medicine and molecular imaging · 2018Article
- Diagnostic performance of fluorine-18 fluorodeoxyglucose positron emission tomography in the management of solitary pulmonary nodule: a meta-analysis.Journal of thoracic disease · 2018Article
- Asymptomatic pulmonary tuberculosis mimicking lung cancer on imaging: A retrospective study.Experimental and therapeutic medicine · 2017Article
- PET/CT in the evaluation of pulmonary solitary nodule.Radiologia brasileiraArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrast-enhanced computed tomography (CECT) and positron emission tomography with 18-FDG (FDG-PET/CT) are used to identify malignant solitary pulmonary nodules. The aim of the study was to evaluate the accuracy of CECT and FDG-PET/CT in diagnosing the etiology of solitary pulmonary nodule (SPN). Eighty patients with newly diagnosed SPN >8 mm were enrolled. The patients were scheduled for either or both, CECT and FDG-PET/CT. The nature of SPN (malignant or benign) was determined either by its pathological examination or radiological criteria. In 71 patients, the etiology of SPN was established and these patients were included in the final analysis. The median SPN diameter in these patients was 13 mm (range 8-30 mm). Twenty-two nodules (31%) were malignant, whereas 49 nodules were benign. FDG-PET/CT was performed in 40 patients, and CECT in 39 subjects. Diagnostic accuracy of CECT was 0.58 (95% confidence interval [CI] 0.41-0.74). The optimal cutoff level discriminating between malignant and benign SPN was an enhancement value of 19 Hounsfield units, for which the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CECT were 100%, 37%, 32%, and 100%, respectively. Diagnostic accuracy of FDG-PET/CT reached 0.9 (95% CI 0.76-0.9). The optimal cutoff level for FDG-PET/CT was maximal standardized uptake value (SUV max) 2.1. At this point, the sensitivity, specificity, PPV, and NPV were 77%, 92%, 83%, and 89%, respectively. The diagnostic accuracy of FDG-PET/CT is higher than that of CECT. The advantage of CECT is its high sensitivity and negative predictive value.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.