Evidence map›Paper›PMID 25881573›Full record

ArticleJournal of oral microbiology2015

Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin.

Rolf Claesson, Jan Gudmundson, Carola Höglund Åberg, Dorte Haubek, Anders Johansson

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Fimbriae potentiateCurrent research in microbial sciences · 2026
    Review
  4. Carriage of the JP2 Genotype ofPathogens (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research.Advances in experimental medicine and biology · 2022
    Article
  7. Article
  8. Journal of clinical medicine · 2021
    Article
  9. Prevalence of JP2 and Non-JP2 Genotypes ofPathogens (Basel, Switzerland) · 2021
    Article
  10. Multilocus Sequence Typing of Non-JP2 Serotype bFrontiers in cellular and infection microbiology · 2021
    Article
  11. Characterization ofVaccines · 2020
    Article
  12. Pathogens (Basel, Switzerland) · 2019
    Review
  13. Virulence and Pathogenicity Properties ofPathogens (Basel, Switzerland) · 2019
    Review
  14. Genetic Profiling ofPathogens (Basel, Switzerland) · 2019
    Article
  15. Tools ofJournal of clinical medicine · 2019
    Review
  16. Age-related prevalence and characteristics ofJournal of oral microbiology · 2017
    Article
  17. Effects ofJournal of oral microbiology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rolf ClaessonDivision of Oral Microbiology, Department of Odontology, Umeå University, Umeå, Sweden; rolf.claesson@odont.umu.se.
Jan GudmundsonPeriodontology Specialist Clinic, Östersunds Hospital, Östersund, Sweden.
Carola Höglund ÅbergDivision of Molecular Periodontology, Department of Odontology, Umeå University, Umeå, Sweden.
Dorte HaubekSection for Pediatric Dentistry, Department of Dentistry, Health, Aarhus University, Aarhus, Denmark.
Anders JohanssonDivision of Molecular Periodontology, Department of Odontology, Umeå University, Umeå, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of the leukotoxin of Aggregatibacter actinomycetemcomitans is regulated by the leukotoxin promoter. A 530-bp deletion or an 886-bp insertion sequence (IS) element in this region has earlier been described in highly leukotoxic isolates. Here, we report on highly leukotoxic isolate with a 640-bp deletion, which was detected in an adolescent of Ethiopian origin.

Indexed as

Africaaggressive periodontitisdeletiongeographic spreadingJP2leukotoxicity

Identifiers

PMID25881573
PMCPMC4400299

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.