ArticleOncotarget2015
Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Research progress on RNA-binding proteins in breast cancer.Oncology letters · 2022Review
- SMC1A regulated by KIAA1429 in m6A-independent manner promotes EMT progress in breast cancer.Molecular therapy. Nucleic acids · 2022Article
- RBM38 is negatively regulated by miR-320b and enhances Adriamycin resistance in breast cancer cells.Oncology letters · 2022Article
- RBM38 in cancer: role and mechanism.Cellular and molecular life sciences : CMLS · 2021Review
- RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Cell death & disease · 2020Article
- Oncogenic action of the exosome cofactor RBM7 by stabilization of CDK1 mRNA in breast cancer.NPJ breast cancer · 2020Article
- RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.Theranostics · 2020Article
- Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer.Pharmacology & therapeutics · 2019Review
- The RNA binding protein RBMS3 inhibits the metastasis of breast cancer by regulating Twist1 expression.Journal of experimental & clinical cancer research : CR · 2019Article
- RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer.Journal of experimental & clinical cancer research : CR · 2018Article
- Genetic Ablation ofCancer research · 2018Article
- PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer.Journal of experimental & clinical cancer research : CR · 2017Article
- RBM38 is involved in TGF-β-induced epithelial-to-mesenchymal transition by stabilising zonula occludens-1 mRNA in breast cancer.British journal of cancer · 2017Article
- The role of c-Myc-RBM38 loop in the growth suppression in breast cancer.Journal of experimental & clinical cancer research : CR · 2017Article
- RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer.Oncotarget · 2017Article
- Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogen receptors (ERs), including ERα and ERβ, mainly mediate the genotype effect of estrogen. ERα is highly expressed in most breast cancers. Endocrine therapy is the most effective and safety adjunctive therapy for ER positive breast cancers. RNPC1, an RNA binding protein (RBP), post-transcriptionally regulating gene expression, is emerging as a critical mechanism for gene regulation in mammalian cells. In this study, we revealed RNPC1's capability of regulating ERα expression. There was a significant correlation between RNPC1 and ERα expression in breast cancer tissues. Ectopic expression of RNPC1 could increase ERα transcript and expression in breast cancer cells, and vice versa. Consistent with this, RNPC1 was able to bind to ERα transcript to increase its stability. Furthermore, overexpression of ERα could decrease the level of RNPC1 transcript and protein. It suggested a novel mechanism by which ERα expression was regulated via stabilizing mRNA. A regulatory feedback loop between RNPC1 and ERα was proved. It indicated that RNPC1 played a crucial role in ERα regulation in ER-positive breast cancers via binding to ERα mRNA. These findings might provide new insights into breast cancer endocrine therapy and ERα research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.