ArticlePloS one2015
BMI and lifetime changes in BMI and cancer mortality risk.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 10 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies.BMC medicine · 2022Pooled it
- Scoping Review and Meta-Analysis Suggests thatCannabis and cannabinoid research · 2021Pooled it
- The predictive value of body mass index on prognosis and adverse events of cancers treated with immunotherapy: a systematic review and meta-analysis.Cancer immunology, immunotherapy : CII · 2021Pooled it
- Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- The association ofBioscience reports · 2019Pooled it
- Body mass index and mortality in lung cancer patients: a systematic review and meta-analysis.European journal of clinical nutrition · 2018Pooled it
- High-intensity exercise interventions in cancer survivors: a systematic review exploring the impact on health outcomes.Journal of cancer research and clinical oncology · 2018Pooled it
- Pooled it
- Pooled it
- Body mass index and mortality in prostate cancer patients: a dose-response meta-analysis.Prostate cancer and prostatic diseases · 2016Pooled it
- Anticoagulants and cancer mortality in the Finnish randomized study of screening for prostate cancer.Cancer causes & control : CCC · 2019Trial
- Methodological considerations for disentangling a risk factor's influence on disease incidence versus postdiagnosis survival: The example of obesity and breast and colorectal cancer mortality in the Women's Health Initiative.International journal of cancer · 2017Trial
- Circulating PCSK9: A new frontier in cancer risk stratification for obese diabetics.Oncology letters · 2026Article
- Healthy lifestyles, screening, and breast cancer mortality in women with different risk of disease.The oncologist · 2025Article
- Multiomics insights into BMI-related intratumoral microbiota in gastric cancer.Frontiers in cellular and infection microbiology · 2025Article
- Review
- An Assessment of Behavioral Risk Factors in Oncology Patients.Nutrients · 2024Article
- The importance of missing data in estimating BMI trajectories.Scientific reports · 2024Article
- Parental Divorce in Childhood and the Accelerated Epigenetic Aging for Earlier and Later Cohorts: Role of Mediators of Chronic Depressive Symptoms, Education, Smoking, Obesity, and Own Marital Disruption.Journal of population ageing · 2024Article
- The association between BMI and self-reported health among a Brazilian sample: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body Mass Index (BMI) is known to be associated with cancer mortality, but little is known about the link between lifetime changes in BMI and cancer mortality in both males and females. We studied the association of BMI measurements (at baseline, highest and lowest BMI during the study-period) and lifetime changes in BMI (calculated over different time periods (i.e. short time period: annual change in BMI between successive surveys, long time period: annual change in BMI over the entire study period) with mortality from any cancer, and lung, colorectal, prostate and breast cancer in a large cohort study (n=8,645. Vlagtwedde-Vlaardingen, 1965-1990) with a follow-up on mortality status on December 31st 2008. We used multivariate Cox regression models with adjustments for age, smoking, sex, and place of residence. Being overweight at baseline was associated with a higher risk of prostate cancer mortality (hazard ratio (HR) =2.22; 95% CI 1.19-4.17). Obesity at baseline was associated with a higher risk of any cancer mortality [all subjects (1.23 (1.01-1.50)), and females (1.40 (1.07-1.84))]. Chronically obese females (females who were obese during the entire study-period) had a higher risk of mortality from any cancer (2.16 (1.47-3.18), lung (3.22 (1.06-9.76)), colorectal (4.32 (1.53-12.20)), and breast cancer (2.52 (1.15-5.54)). We found no significant association between long-term annual change in BMI and cancer mortality risk. Both short-term annual increase and decrease in BMI were associated with a lower mortality risk from any cancer [all subjects: (0.67 (0.47-0.94)) and (0.73 (0.55-0.97)), respectively]. In conclusion, a higher BMI is associated with a higher cancer mortality risk. This study is the first to show that short-term annual changes in BMI were associated with lower mortality from any type of cancer.
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