ArticleBMC neuroscience2015
Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts.
Article in BMC neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Age-dependent regenerative mechanisms in the brain.Biochemical Society transactions · 2024Review
- Transient neurogenesis in ischemic cortex from Sox2Neural regeneration research · 2023Article
- Consistency and Variation in Doublecortin and Ki67 Antigen Detection in the Brain Tissue of Different Mammals, including Humans.International journal of molecular sciences · 2023Article
- Adult Neurogenesis and Stroke: A Tale of Two Neurogenic Niches.Frontiers in neuroscience · 2021Review
- EndoN treatment allows neuroblasts to leave the rostral migratory stream and migrate towards a lesion within the prefrontal cortex of rats.Neural regeneration research · 2020Article
- Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.CNS neuroscience & therapeutics · 2020Article
- Growth Hormone Promotes Motor Function after Experimental Stroke and Enhances Recovery-Promoting Mechanisms within the Peri-Infarct Area.International journal of molecular sciences · 2020Article
- Excitable Adult-Generated GABAergic Neurons Acquire Functional Innervation in the Cortex after Stroke.Stem cell reports · 2018Article
- Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs.BMC neuroscience · 2018Article
- Doublecortin-expressing cell types in temporal lobe epilepsy.Acta neuropathologica communications · 2018Article
- Redirection of neuroblast migration from the rostral migratory stream into a lesion in the prefrontal cortex of adult rats.Experimental brain research · 2018Article
- Effect of skilled reaching training and enriched environment on generation of oligodendrocytes in the adult sensorimotor cortex and corpus callosum.BMC neuroscience · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the recovery of functional deficits after stroke though the nature and origin of these cells remains unclear.
resultsIn the present study, we aimed to characterize the population of DCX+ cells in the vicinity of ischemic infarcts in a mouse model in detail. Employing a photothrombosis model, distinct immunohistochemical techniques, stereology and confocal microscopy, we show that: i) DCX+ cells in the perilesional zone do not constitute a homogenous population and two cell types, stellate and polar cells can be distinguished according to their morphology. ii) Stellate cells are mainly located in the lateral and medial vicinity of the insult and express astrocytic markers. iii) Polar cells are found almost exclusively in the corpus callosum region including in the preserved deep cortical layers close to the subventricular zone (SVZ). Further, they do not show any colocalisation of glial markers. Polar morphology and distribution suggest a migration towards the lesion.
conclusionsIn summary, our findings provide evidence that in mice DCX+ cells in the perilesional zone of cortical infarcts comprise a distinct cell population and the majority of cells are of glial nature.
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