ArticleBMC evolutionary biology2015
Immunity, suicide or both? Ecological determinants for the combined evolution of anti-pathogen defense systems.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Eco-evolutionary dynamics of defense systems in mobile genetic elements: Cui bono?Research square · 2026Article
- Eco-evolutionary dynamics of defense systems in mobile genetic elements: Cui bono?bioRxiv : the preprint server for biology · 2026Article
- Ecological determinants of altruism in prokaryote antivirus defense.Biology direct · 2025Article
- Expression level of anti-phage defence systems controls a trade-off between protection range and autoimmunity.Nature microbiology · 2025Article
- Ecological determinants of altruism in prokaryote antivirus defense.Research square · 2025Article
- The polinton-like supergroup of viruses: evolution, molecular biology, and taxonomy.Microbiology and molecular biology reviews : MMBR · 2024Review
- Dynamics of CRISPR-mediated virus-host interactions in the human gut microbiome.The ISME journal · 2024Article
- Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?Biochemistry. Biokhimiia · 2022Review
- Coevolutionary theory of hosts and parasites.Journal of evolutionary biology · 2022Review
- Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.Nature reviews. Microbiology · 2020Review
- Game-Theoretical Modeling of Interviral Conflicts Mediated by Mini-CRISPR Arrays.Frontiers in microbiology · 2020Article
- Origin of programmed cell death from antiviral defense?Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Adaptive suicide: is a kin-selected driver of fatal behaviours likely?Biology letters · 2019Review
- CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology.Biology & philosophy · 2019Article
- Selective Maintenance of Multiple CRISPR Arrays Across Prokaryotes.The CRISPR journal · 2018Article
- Disentangling the effects of selection and loss bias on gene dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Diversity and evolution of class 2 CRISPR-Cas systems.Nature reviews. Microbiology · 2017Article
- Prokaryotic Virus Orthologous Groups (pVOGs): a resource for comparative genomics and protein family annotation.Nucleic acids research · 2017Article
- Phage "delay" towards enhancing bacterial escape from biofilms: a more comprehensive way of viewing resistance to bacteriophages.AIMS microbiology · 2017Article
- Bacteriophages affect evolution of bacterial communities in spatially distributed habitats: a simulation study.BMC microbiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundParasite-host arms race is one of the key factors in the evolution of life. Most cellular life forms, in particular prokaryotes, possess diverse forms of defense against pathogens including innate immunity, adaptive immunity and programmed cell death (altruistic suicide). Coevolution of these different but interacting defense strategies yields complex evolutionary regimes.
resultsWe develop and extensively analyze a computational model of coevolution of different defense strategies to show that suicide as a defense mechanism can evolve only in structured populations and when the attainable degree of immunity against pathogens is limited. The general principle of defense evolution seems to be that hosts do not evolve two costly defense mechanisms when one is sufficient. Thus, the evolutionary interplay of innate immunity, adaptive immunity and suicide, leads to an equilibrium state where the combination of all three defense strategies is limited to a distinct, small region of the parameter space. The three strategies can stably coexist only if none of them are highly effective. Coupled adaptive immunity-suicide systems, the existence of which is implied by the colocalization of genes for the two types of defense in prokaryotic genomes, can evolve either when immunity-associated suicide is more efficacious than other suicide systems or when adaptive immunity functionally depends on the associated suicide system.
conclusionsComputational modeling reveals a broad range of outcomes of coevolution of anti-pathogen defense strategies depending on the relative efficacy of different mechanisms and population structure. Some of the predictions of the model appear compatible with recent experimental evolution results and call for additional experiments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.