ArticleBMC infectious diseases2015
Acinetobacter calcoaceticus from a fatal case of pneumonia harboring bla(NDM-1) on a widely distributed plasmid.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Clinical Implications of Bacteremia Caused by Non-Biomedicines · 2025Article
- Prevalence of Antibiotic Resistance Genes in Differently Processed Smoothies and Fresh Produce from Austria.Foods (Basel, Switzerland) · 2024Article
- Article
- Genetic Resistance Determinants in ClinicalAntibiotics (Basel, Switzerland) · 2022Article
- Phage-delivered sensitisation with subsequent antibiotic treatment reveals sustained effect against antimicrobial resistant bacteria.Theranostics · 2020Article
- Chromosome Architecture and Gene Content of the Emergent PathogenFrontiers in microbiology · 2020Article
- Multidrug-resistantExperimental and therapeutic medicine · 2019Article
- Genomic Epidemiology of NDM-1-Encoding Plasmids in Latin American Clinical Isolates Reveals Insights into the Evolution of Multidrug Resistance.Genome biology and evolution · 2017Article
- First report of Oxa-72-producing Acinetobacter calcoaceticus in Lebanon.New microbes and new infections · 2016Article
- Reservoirs of Non-baumannii Acinetobacter Species.Frontiers in microbiology · 2016Review
- Article
- Motif-Based Text Mining of Microbial Metagenome Redundancy Profiling Data for Disease Classification.BioMed research international · 2016Article
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10 authors.
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Abstract
backgroundWe have recovered one bla(NDM-1)-harboring bacterial strain, designated as XM1570, from a sputum sample obtained from a fatal case of pneumonia in China.
methodsBiochemical profiling, 16S rRNA sequencing and antimicrobial susceptibility testing were performed. Conjugation experiments were conducted to determine transmissibility of resistance. Pulsed-field gel electrophoresis and whole genome sequencing were performed to identify strain-specific features.
resultsThe isolate XM1570 was identified as Acinetobacter calcoaceticus. Whole genome sequencing identified two plasmids, pXM1 and pXM2. Comparative analysis showed >99% similarity between XM1570 and A. calcoaceticus PHEA-2. Plasmid pXM1 carried the carbapenemase gene bla(NDM-1) and displayed high homology with previously described plasmids isolated from different Acinetobacter spp., which were collected from human or livestock distributed in China and worldwide. The bla(NDM-1) gene was located on this conjugative plasmid in a transposon-like region flanked by two copies of the insertion sequence ISAba125; and resistance to all tested β-lactams was observed. Transferability of resistance from pXM1 to the transconjugants was identified. Plasmid pXM2 had an insertion sequence ISAba125 and a -35 region of the bla NDM-1 gene promoter but the bla NDM-1 gene was not present. A chromosomally located carbapenemase-encoding gene bla OXA-75 was detected; however, this gene was interrupted by an insertion sequence ISAba22 belonging to IS3 family.
conclusionsLocation of bla(NDM-1) on different self-transmissible plasmids could facilitate geographically broad dissemination and host range expansion of the bla(NDM-1) gene via horizontal gene transfer. Our findings of this normally environmental species A. calcoaceticus XM1570 further underline the significant clinical challenge and the essential need for surveillance including molecular methods and plasmid analyses.
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