Trial reportBMC ophthalmology2015
Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study.
Trial report in BMC ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms
Neural Compensation, Visual Function and Visual Quality in Senile Cataract Patients After Monofocal or Multifocal Intraocular Lens Implantation
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Pooled it
- Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders.International ophthalmology · 2021Trial
- Effects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial.Scientific reports · 2019Trial
- Efficacy of an ocular bandage contact lens for the treatment of dry eye after phacoemulsification.BMC ophthalmology · 2019Trial
- Comparative Efficacy of Topical Eye-Drop Regimens for Dry Eye After Cataract Surgery: A Systematic Review and Network Meta-analysis.Ophthalmology and therapy · 2026Review
- Can the choice of artificial tears harm patients? A narrative review with an overview of the Nordic market.Acta ophthalmologica · 2025Review
- Effect of different incisions on dry eye symptoms after cataract surgery in diabetic patients.BMC ophthalmology · 2025Article
- Assessing the Effects of 0.3% Carboxymethylcellulose Tear Substitute Treatment on Symptoms and Signs of Dry Eye Disease in Elderly Population: A Prospective Longitudinal Study.Journal of clinical medicine · 2023Article
- Comparing the efficacy of sodium hyaluronate eye drops and carboxymethylcellulose eye drops in treating mild to moderate dry eye disease.Indian journal of ophthalmology · 2023Observational
- Cataract surgery in ocular surface disease.Indian journal of ophthalmology · 2023Review
- Randomised, Single Blind, Controlled, Three-Month Clinical Trial on the Evaluation and Treatment of the Ocular Surface Damage Following Phacoemulsification.Vision (Basel, Switzerland) · 2022Article
- Comparative antioxidant activity of various ophthalmic product types for artificial tears under different experimental conditions.Experimental and therapeutic medicine · 2022Article
- Effects of cataract surgery on symptoms and findings of dry eye in subjects with and without preexisting dry eye.Japanese journal of ophthalmology · 2020Article
- The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Prevalence of Dry Eye and its Subtypes in an Elderly Population with Cataracts in Indonesia.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- The assessment of the impact of glistening on visual performance in relation to tear film quality.PloS one · 2020Observational
- Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients.Journal of clinical medicine · 2019Article
- Hydroxypropyl methylcellulose 2% for dry eye prevention during phacoemulsification in senile and diabetic patients.International ophthalmology · 2018Article
- Comparative study of 0.1% hyaluronic acid versus 0.5% carboxymethylcellulose in patients with dry eye associated with moderate keratitis or keratoconjunctivitis.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor patients who experience dry eye after phacoemulsification, vision and quality of life can significantly deteriorate. In this study, the efficacy and safety of carboxymethylcellulose sodium (CMC) 1% ophthalmic solution combined with conventional therapy in treating dry eye signs and symptoms after phacoemulsification were evaluated.
methodsIn this prospective, multicenter, open-label, controlled study, 180 patients with age-related cataract were randomized to treatment with conventional therapy plus CMC 1% (n = 90) or to conventional therapy only (control group, n = 90) after phacoemulsification and intraocular lens implantation. Tear breakup time (TBUT), the Schirmer test with anesthesia, and fluorescein and lissamine green staining were performed. The Ocular Surface Disease Index (OSDI) questionnaire and a patient subjective symptom evaluation were administered preoperatively (baseline) and postoperatively at 7 and 30 days.
resultsTBUT was significantly longer in the treatment group compared with the control group at day 7 (8.5 ± 5.5 versus 6.6 ± 3.8 s; P = 0.0475) and day 30 (9.0 ± 5.9 versus 6.7 ± 4.8 s; P = 0.0258) after surgery. Compared with baseline, TBUT significantly increased in patients in the treatment group (P < 0.001 at both day 7 and day 30) with a presurgical diagnosis of dry eye, but significantly decreased in patients in the control group (P < 0.02 at both day 7 and day 30) with no prior diagnosis of dry eye. Fluorescein and lissamine staining, OSDI questionnaire and subjective symptom scores all improved from baseline, with no significant differences between the two groups. No significant differences in tolerability and safety were observed between the group receiving CMC and conventional therapy, and those receiving conventional therapy only.
conclusionTreatment with CMC 1% can provide significant improvement in tear film stability after phacoemulsification for age-related cataract.
trial registrationClinicalTrials.gov identifier NCT02028754 (Date of registration: Jan. 6, 2014).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.