ArticleMalaria journal2015
Epidemiology of forest malaria in Central Vietnam: the hidden parasite reservoir.
Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Placebo-controlled, Double-blind Trial Using Dihydroartemisinine+Piperaquine (DP) to Protect Forest Workers From Malaria in Bu Gia Map National Park
An Open-label Individually Randomised Controlled Trial to Assess the Efficacy of Artemether-lumefantrine Prophylaxis for Malaria Among Forest Goers in Cambodia
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and proportion estimate of asymptomatic Plasmodium infection in Asia: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Residual Malaria Transmission in Select Countries of Asia-Pacific Region: Old Wine in a New Barrel.The Journal of infectious diseases · 2021Pooled it
- The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial.PLoS medicine · 2019Trial
- A Controlled Trial of Mass Drug Administration to Interrupt Transmission of Multidrug-Resistant Falciparum Malaria in Cambodian Villages.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Confirmed Plasmodium vivax Resistance to Chloroquine in Central Vietnam.Antimicrobial agents and chemotherapy · 2015Trial
- Malaria situation in a highly endemic province in the Central Highlands of Vietnam: a retrospective analysis.Malaria journal · 2026Article
- Molecular Profiles of Antimalarial Drug Resistance inMicroorganisms · 2025Article
- Asymptomatic/submicroscopicParasite epidemiology and control · 2025Article
- Bayesian spatio-temporal modelling of environmental, climatic, and socio-economic influences on malaria in Central Vietnam.Malaria journal · 2024Article
- Potential distribution of malaria vectors in Central Vietnam: A MaxEnt modeling approach.Veterinary world · 2024Article
- 'Forest malaria' in Myanmar? Tracking transmission landscapes in a diversity of environments.Parasites & vectors · 2023Article
- Fever and health-seeking behaviour among migrants living along the Thai-Myanmar border: a mixed-methods study.BMC infectious diseases · 2023Article
- Mosquitoes and Mosquito-Borne Diseases in Vietnam.Insects · 2022Review
- Risk factors associated with malaria infection along China-Myanmar border: a case-control study.Malaria journal · 2022Article
- Understanding the epidemiology, clinical characteristics, knowledge and barriers to treatment and prevention of malaria among returning international laborers in northern Vietnam: a mixed-methods study.BMC infectious diseases · 2022Article
- Malaria from hyperendemicity to elimination along international borders in Yunnan, China during 2003‒2020: a case study.Infectious diseases of poverty · 2022Article
- Why using bed nets is a challenge among minority populations in Central Vietnam.Malaria journal · 2022Article
- Epidemiological characteristics ofFrontiers in cellular and infection microbiology · 2022Article
- Intensive surveillance, rapid response and border collaboration for malaria elimination: China Yunnan's ''3 + 1''strategy.Malaria journal · 2021Review
- In search of the last malaria cases: ethnographic methods for community and private-sector engagement in malaria elimination in Vietnam, Laos, and Cambodia.Malaria journal · 2021Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter successfully reducing the malaria burden to pre-elimination levels over the past two decades, the national malaria programme in Vietnam has recently switched from control to elimination. However, in forested areas of Central Vietnam malaria elimination is likely to be jeopardized by the high occurrence of asymptomatic and submicroscopic infections as shown by previous reports. This paper presents the results of a malaria survey carried out in a remote forested area of Central Vietnam where we evaluated malaria prevalence and risk factors for infection.
methodsAfter a full census (four study villages = 1,810 inhabitants), the study population was screened for malaria infections by standard microscopy and, if needed, treated according to national guidelines. An additional blood sample on filter paper was also taken in a random sample of the population for later polymerase chain reaction (PCR) and more accurate estimation of the actual burden of malaria infections. The risk factor analysis for malaria infections was done using survey multivariate logistic regression as well as the classification and regression tree method (CART).
resultsA total of 1,450 individuals were screened. Malaria prevalence by microscopy was 7.8% (ranging from 3.9 to 10.9% across villages) mostly Plasmodium falciparum (81.4%) or Plasmodium vivax (17.7%) mono-infections; a large majority (69.9%) was asymptomatic. By PCR, the prevalence was estimated at 22.6% (ranging from 16.4 to 42.5%) with a higher proportion of P. vivax mono-infections (43.2%). The proportion of sub-patent infections increased with increasing age and with decreasing prevalence across villages. The main risk factors were young age, village, house structure, and absence of bed net.
conclusionThis study confirmed that in Central Vietnam a substantial part of the human malaria reservoir is hidden. Additional studies are urgently needed to assess the contribution of this hidden reservoir to the maintenance of malaria transmission. Such evidence will be crucial for guiding elimination strategies.
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