ArticleJournal of human hypertension2016
Potential effects of age on screening for primary aldosteronism.
Article in Journal of human hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Optimal Cut-Off Values of the Aldosterone-Renin Ratio in Different Age Groups for Primary Aldosteronism Screening.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Effect of Age on Aldosterone-Renin Ratio in Screening Primary Aldosteronism.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Occurrence of Metabolic Disorders in Bilateral Primary Aldosteronism Compared to Unilateral Primary Aldosteronism.Diseases (Basel, Switzerland) · 2025Article
- Comparison of saline infusion test and captopril challenge test in the diagnosis of Chinese with primary aldosteronism in different age groups.Frontiers in endocrinology · 2024Observational
- Higher plasma renin activity is associated with increased kidney damage risk in patients with hypertension and glucose metabolic disorders.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism: a systematic review and meta-analysis.Annals of translational medicine · 2022Article
- Plasma aldosterone concentration is associated with white matter lesions in patients with primary aldosteronism.Endocrine · 2022Article
- Long-term impact of spironolactone compliance on microalbuminuria in patients with primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Confounders of the aldosterone-to-renin ratio when used as a screening test in hypertensive patients: A critical analysis of the literature.Journal of clinical hypertension (Greenwich, Conn.) · 2021Review
- Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension.Frontiers in endocrinology · 2021Article
- Minor Change of Plasma Renin Activity during the Saline Infusion Test Provide an Auxiliary Diagnostic Value for Primary Aldosteronism.International journal of endocrinology · 2021Article
- Abdominal aortic calcification is more severe in unilateral primary aldosteronism patients and is associated with elevated aldosterone and parathyroid hormone levels.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Primary aldosteronism in elderly, old, and very old patients.Journal of human hypertension · 2020Review
- Mild primary aldosteronism (PA) followed by overt PA are possibly the most common forms of low renin hypertension: a single-center retrospective study.Journal of human hypertension · 2020Article
- The Association between eGFR and the Aldosterone-to-Renin Ratio and Its Effect on Screening for Primary Aldosteronism.International journal of endocrinology · 2020Article
- Age-Related Cutoffs of Plasma Aldosterone/Renin Concentration for Primary Aldosteronism Screening.International journal of endocrinology · 2018Article
- Bypass of confirmatory tests for case detection of primary aldosteronism in leaner patients?Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Association Between Polymorphisms of ADRBK1 Gene and Plasma Renin Activity in Hypertensive Patients: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aldosterone/renin ratio (ARR) is currently regarded as the most reliable and available screening test for primary aldosteronism (PA), however, the falling accuracy of ARR with increasing age has posed crucial challenge for PA screening among older-aged population. To clarify potential effects of age on screening for PA, 216 subjects with PA and 657 subjects with non-PA were recruited and subdivided into four age groups (⩽39, 40-49, 50-59 and ⩾60 years) and their biochemical parameters were compared. As expected, plasma renin activity (PRA) lowered more than plasma aldosterone concentration (PAC) and led to gradually elevated ARR with increasing age in the non-PA group (P<0.001), whereas this phenomenon was unconspicuous in the PA group. The best cut-off values of ARR for PA screening were elevated in subjects ⩾50 years, whereas the area under the receiver operating characteristic curves (AUCs), sensitivity, specificity and Youden's index (YI) of ARR were declined with increasing age, especially in patients ⩾60 years (AUC=0.863, sensitivity=95.2%, specificity=69.0%, YI=0.643). The AUCs of PAC increased with increasing age and even slightly surpassed that of ARR in patients ⩾60 years (AUCPAC=0.884). Our data suggest that the criteria of ARR for PA screening in patients ⩾50 years may need setting higher; the falling accuracy of ARR with increasing age, especially in patients ⩾60 years, could be improved by taking into account the absolute value of the PAC when applicable by the center.
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