ArticleBMC infectious diseases2015
Molecular epidemiology of human sporotrichosis in Venezuela reveals high frequency of Sporothrix globosa.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 55 citations in OpenAlex.
- Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review.Medical mycology case reports · 2025Article
- Sporothrix is neglected among the neglected.PLoS pathogens · 2025Article
- Phenotypic and genotypic characterization of Colombian clinical isolates of Sporothrix spp.Biomedica : revista del Instituto Nacional de Salud · 2023Article
- High-Throughput Microsatellite Markers Development for Genetic Characterization of EmergingJournal of fungi (Basel, Switzerland) · 2023Article
- Sporotrichosis Outbreak Due toJournal of fungi (Basel, Switzerland) · 2023Article
- Trends in Molecular Diagnostics and Genotyping Tools Applied for EmergingJournal of fungi (Basel, Switzerland) · 2022Review
- Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends.Journal of fungi (Basel, Switzerland) · 2022Review
- Article
- Withania somnifera (L.) Dunal whole-plant extracts exhibited anti-sporotrichotic effects by destabilizing peripheral integrity of Sporothrix globosa yeast cells.PLoS neglected tropical diseases · 2022Article
- Epidemiology of Clinical Sporotrichosis in the Americas in the Last Ten Years.Journal of fungi (Basel, Switzerland) · 2022Review
- Clinical, Epidemiological, and Epizootic Features of Sporothrix brasiliensis in Espírito Santo, Brazil.EcoHealth · 2022Article
- Biological and Clinical Attributes ofInfection and drug resistance · 2022Review
- Sporotrichosis in Children: Case series and Narrative Review.Current fungal infection reports · 2022Review
- Phenotypic and molecular characterisation of Sporothrix globosa of diverse origin from India.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Geographical distribution and ecological niche modeling of the etiological agents of human sporotrichosis in Venezuela.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Sporothrix globosa melanin inhibits antigenpresentation by macrophages and enhances deep organ dissemination.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Article
- Influences of the Culturing Media in the Virulence and Cell Wall ofJournal of fungi (Basel, Switzerland) · 2020Article
- The threat of emerging and re-emerging pathogenic Sporothrix species.Mycopathologia · 2020Review
- Comparative Genomic Data Provide New Insight on the Evolution of Pathogenicity inFrontiers in microbiology · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSporotrichosis is a cutaneous and subcutaneous fungal disease of humans and other mammals, known to be caused by the Sporothrix schenckii species complex, which comprises four species of clinical importance: S. brasiliensis, S. globosa, S. luriei, and S. schenckii sensu stricto. Of them, S. globosa and S. schenckii s. str. show global distribution and differences in global frequency as causal agents of the disease. In the Americas, only three species are present: S. schenckii s. str., S. brasiliensis (so far, only reported in Brazil), and S. globosa. In Venezuela, since the first case of sporotrichosis reported in 1935, S. schenckii have been considered its unique etiological agent. In the present work, the presence of more than one species in the country was evaluated.
methodsBy phenotypic key features and molecular phylogeny analyses, we re-examined 30 isolates from diverse Venezuelan regions belonging to the fungi collection of Instituto de Biomedicina, Caracas, Venezuela, and national reference center for skin diseases. All isolates were collected between 1973 and 2013, and maintained in distilled water.
resultsSporotrichosis in Venezuela is mainly caused by S. schenckii s. str. (70%). However, a significant proportion (30%) of sporotrichosis cases in the country can be attributable to S. globosa. A correlation between intraspecific genotypes and clinical presentation is proposed.
conclusionsOur data suggest that sporotrichosis various clinical forms might be related to genetic diversity of isolates, and possibly, to diverse virulence profiles previously reported in the S. schenckii species complex. Sporothrix globosa was found to be the causative agent of 30% of sporotrichosis for the Venezuelan cases re-examined, the highest frequency of this species so far reported in the Americas. The high genetic variability presented by S. schenckii s. str. indicates that species distinction based on phenotypic key features could be a challenging and uncertain task; molecular identification should be always employed.
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