ArticleCritical care (London, England)2015
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Microfluidics and Transcriptomics to Implement Precision Medicine in Post Solid Organ Transplant Patients
Hip Fracture Epidemiology at Hospital Regional Rafael Hernandez. September 2014 to March 2015.
Who cites it
48 citing papers in PubMed, 79 citations in OpenAlex.
- Implementation of new standard operating procedures for geriatric trauma patients with multiple injuries: a single level I trauma centre study.BMC geriatrics · 2019Trial
- Pirinixic Acid Protects Against Hemorrhagic Shock by Regulating Neutrophil-Associated Key Genes.Shock (Augusta, Ga.) · 2026Article
- Trauma as a critical condition in the very old: assessment, care pathways and outcome differences.European geriatric medicine · 2026Review
- Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction.Signal transduction and targeted therapy · 2025Article
- Biological age in critical care: current evidence, future prospects, and clinical implications.Frontiers in medicine · 2025Review
- Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic shock.Apoptosis : an international journal on programmed cell death · 2024Article
- Protective Effects and Mechanisms of Inhibiting Endoplasmic Reticulum Stress on Cold Seawater Immersion Combined with Hemorrhagic Shock.Journal of inflammation research · 2024Article
- Surgical Treatment versus Conservative Management of Splenic Rupture: Outcomes and Risk Factors.Bulletin of emergency and trauma · 2024Article
- Identification of potential biomarkers and therapeutic targets for posttraumatic acute respiratory distress syndrome.BMC medical genomics · 2023Article
- Fracture Healing in Elderly Mice and the Effect of an Additional Severe Blood Loss: A Radiographic and Biomechanical Murine Study.Bioengineering (Basel, Switzerland) · 2023Article
- Cytokine Pathways in Cardiac Dysfunction following Burn Injury and Changes in Genome Expression.Journal of personalized medicine · 2022Review
- Importance of the neutrophil‑to‑lymphocyte ratio as a prognostic factor in patients with spleen trauma: A single center experience.Biomedical reports · 2022Article
- [Early changes within the lymphocyte population are associated with the long term prognosis in severely injured patients].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- The endothelial glycocalyx in critical illness: A pediatric perspective.Matrix biology plus · 2022Article
- Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients: A Multicenter Prospective Observational Study.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022Article
- Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response.Aging and disease · 2022Article
- Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Challenges in the PREHOSPITAL emergency management of geriatric trauma patients - a scoping review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Article
- Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock.GeroScience · 2021Article
- A putative "chemokine switch" that regulates systemic acute inflammation in humans.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
introductionWe wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemorrhagic shock.
methodsWe performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients.
resultsWe found that there was no difference in injury severity between the aged (age ≥55, n = 533) and young (age <55, n = 1395) cohorts. However, aged patients had more comorbidities. Advanced age was associated with more severe organ failure, infectious complications, ventilator days, and intensive care unit length of stay, as well as, an increased likelihood of being discharged to skilled nursing or long-term care facilities. Additionally, advanced age was an independent predictor of a complicated recovery and 28-day mortality. Acutely after trauma, blood neutrophil genome-wide expression analysis revealed an attenuated transcriptomic response as compared to the young; this attenuated response was supported by the patients' plasma cytokine and chemokine concentrations. Later, these patients demonstrated gene expression changes consistent with simultaneous, persistent pro-inflammatory and immunosuppressive states.
conclusionsWe concluded that advanced age is one of the strongest non-injury related risk factors for poor outcomes after severe trauma with hemorrhagic shock and is associated with an altered and unique peripheral leukocyte genomic response. As the general population's age increases, it will be important to individualize prediction models and therapeutic targets to this high risk cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.