ArticleVirology2015
Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak.
Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis.International journal of epidemiology · 2016Pooled it
- The face of Ebola: changing frequency of haemorrhage in the West African compared with Eastern-Central African outbreaks.BMC infectious diseases · 2015Pooled it
- Article
- Molecular adaptations during viral epidemics.EMBO reports · 2022Review
- Investigating the disordered regions (MoRFs, SLiMs and LCRs) and functions of mimicry proteins/peptides in silico.PloS one · 2022Article
- Animal and human RNA viruses: genetic variability and ability to overcome vaccines.Archives of microbiology · 2021Review
- Characterization of Antigenic MHC-Class-I-Restricted T Cell Epitopes in the Glycoprotein of Ebolavirus.Cell reports · 2019Article
- In silico prediction of structural changes in human papillomavirus type 16 (HPV16) E6 oncoprotein and its variants.BMC molecular and cell biology · 2019Article
- Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity.Journal of immunology research · 2018Article
- Filoviruses: Ecology, Molecular Biology, and Evolution.Advances in virus research · 2018Review
- Article
- The 2014 Ebola virus outbreak in West Africa highlights no evidence of rapid evolution or adaptation to humans.Scientific reports · 2016Article
- Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum.The Journal of biological chemistry · 2016Review
- Article
- Article
- New Perspectives on Ebola Virus Evolution.PloS one · 2016Article
- Evolution and Spread of Ebola Virus in Liberia, 2014-2015.Cell host & microbe · 2015Article
- Ebola viral load at diagnosis associates with patient outcome and outbreak evolution.The Journal of clinical investigation · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The 2014 epidemic of Ebola virus disease (EVD) has had a devastating impact in West Africa. Sequencing of ebolavirus (EBOV) from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to humans, accounting for the scale of the 2014 outbreak. We computationally analyze the variation associated with all EVD outbreaks, and find none of the amino acid replacements lead to identifiable functional changes. These changes have minimal effect on protein structure, being neither stabilizing nor destabilizing, are not found in regions of the proteins associated with known functions and tend to cluster in poorly constrained regions of proteins, specifically intrinsically disordered regions. We find no evidence that the difference between the current and previous outbreaks is due to evolutionary changes associated with transmission to humans. Instead, epidemiological factors are likely to be responsible for the unprecedented spread of EVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.