ArticleBMC genomics2015
Ecological genomics in Xanthomonas: the nature of genetic adaptation with homologous recombination and host shifts.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Impact of mineral fertilization andFrontiers in microbiology · 2025Article
- The Multifaceted Role of Homologous Recombination in a Fastidious Bacterial Plant Pathogen.Applied and environmental microbiology · 2023Article
- Unraveling the genetic evolution of SARS-CoV-2 Recombinants using mutational dynamics across the different lineages.Frontiers in medicine · 2023Article
- Pangenome insights into the diversification and disease specificity of worldwideFrontiers in microbiology · 2023Article
- Phylogenetic Distribution and Evolution of Type VI Secretion System in the GenusFrontiers in microbiology · 2022Article
- Trends in Molecular Diagnosis and Diversity Studies for Phytosanitary RegulatedMicroorganisms · 2021Review
- Repeated gain and loss of a single gene modulates the evolution of vascular plant pathogen lifestyles.Science advances · 2020Article
- Xanthomonas diversity, virulence and plant-pathogen interactions.Nature reviews. Microbiology · 2020Review
- NovelFrontiers in microbiology · 2020Article
- Independent Evolution with the Gene Flux Originating from MultipleApplied and environmental microbiology · 2019Article
- Origin and diversification of Xanthomonas citri subsp. citri pathotypes revealed by inclusive phylogenomic, dating, and biogeographic analyses.BMC genomics · 2019Article
- Genome sequence of Xanthomonas fuscans subsp. fuscans strain Xff49: a new isolate obtained from common beans in Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Genomic Inference of Recombination-Mediated Evolution in Xanthomonas euvesicatoria and X. perforans.Applied and environmental microbiology · 2018Article
- Contributions of ancestral inter-species recombination to the genetic diversity of extant Streptomyces lineages.The ISME journal · 2016Article
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComparative genomics provides insights into the diversification of bacterial species. Bacterial speciation usually takes place with lasting homologous recombination, which not only acts as a cohering force between diverging lineages but brings advantageous alleles favored by natural selection, and results in ecologically distinct species, e.g., frequent host shift in Xanthomonas pathogenic to various plants.
resultsUsing whole-genome sequences, we examined the genetic divergence in Xanthomonas campestris that infected Brassicaceae, and X. citri, pathogenic to a wider host range. Genetic differentiation between two incipient races of X. citri pv. mangiferaeindicae was attributable to a DNA fragment introduced by phages. In contrast to most portions of the genome that had nearly equivalent levels of genetic divergence between subspecies as a result of the accumulation of point mutations, 10% of the core genome involving with homologous recombination contributed to the diversification in Xanthomonas, as revealed by the correlation between homologous recombination and genomic divergence. Interestingly, 179 genes were under positive selection; 98 (54.7%) of these genes were involved in homologous recombination, indicating that foreign genetic fragments may have caused the adaptive diversification, especially in lineages with nutritional transitions. Homologous recombination may have provided genetic materials for the natural selection, and host shifts likely triggered ecological adaptation in Xanthomonas. To a certain extent, we observed positive selection nevertheless contributed to ecological divergence beyond host shifting.
conclusionAltogether, mediated with lasting gene flow, species formation in Xanthomonas was likely governed by natural selection that played a key role in helping the deviating populations to explore novel niches (hosts) or respond to environmental cues, subsequently triggering species diversification.
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